bistratene A

from marine invertebrate Lissoclinum bistratum; structure given in first source; also may originate from Urochordata Lissoclinum bistratum Sluiteror or from symbiotic alagae; has high affinity to ACTINS causing depolymerization and interfering with locomotion

Also Known As:

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kozmin, Sergey A: 2 articles (06/2010 - 03/2008)
2.	Rizvi, Syed Alipayam: 2 articles (06/2010 - 03/2008)
3.	Chen, Zhonglei: 1 article (06/2010)
4.	Chmura, Steven J: 1 article (06/2010)
5.	Kovar, David R: 1 article (06/2010)
6.	Liu, Song: 1 article (06/2010)
7.	Pytynia, Matthew: 1 article (06/2010)
8.	Skau, Colleen: 1 article (06/2010)
9.	Beignet, Julien: 1 article (03/2009)
10.	Beutler, John A: 1 article (03/2009)

Related Diseases

1.	Neoplasms (Cancer) 03/18/2008 - "This study provides comprehensive characterization of the mode of action of bistramide A and identifies structural requirements of bistramide-based compounds that are responsible for severing actin filaments and inhibiting growth of cancer cells in vitro and in vivo. " 03/06/2009 - "Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth." 01/01/1988 - "Bistramide A also has a marked cytotoxic effect on cancer cells KB (IC50 = 4.5 x 10(-8) M) and P 388 (IC50 = 2.0 x 10(-8) M) and on normal endothelial cells (IC50 = 2.2 x 10(-8) M). " 06/02/2010 - "We describe structure-based design and chemical synthesis of a simplified analog of bistramide A, which potently and reversibly binds monomeric actin with a K(d) of 9.0 nM, depolymerizes filamentous actin in vitro and in A549 (nonsmall cell lung cancer) cells, inhibits growth of cancer cell lines in vitro at submicromolar concentrations, and significantly suppresses proliferation of A549 cells in a nude mice tumor xenograft model in terms of both tumor growth delay and average tumor volume. "
2.	Leukemia 05/15/1990 - "Bistratene A was toxic to HL-60 human promyelocytic leukemia cells with an IC50 value of 424 nM. At lower concentrations (10-100 nM), bistratene A induced the incomplete differentiation of these cells along the monocyte/macrophage pathway. " 01/01/1994 - "The effects on the cell cycle of two biologically active compounds, bistratene A and cycloxazoline, from the marine ascidian Lissoclinum bistratum were studied in HL-60 human leukemia cells using flow cytometry. " 01/01/1994 - "Accumulation of HL-60 leukemia cells in G2/M and inhibition of cytokinesis caused by two marine compounds, bistratene A and cycloxazoline." 08/01/1992 - "Bistratene A, a polyether toxin isolated from the colonial ascidian Lissoclinum bistratum, causes incomplete differentiation of human leukemia (HL-60) cells apparently through a mechanism not involving protein kinase C. " 08/01/1992 - "Bistratene A: a novel compound causing changes in protein phosphorylation patterns in human leukemia cells."
3.	Polyploidy 06/24/1999 - "Consequently, bistratene A-treated cells became polyploid and multinucleate. " 01/01/1991 - "Bistramide A has a dual mechanism that induces blockade in the G1 phase (compatible with differentiation properties reported elsewhere) and causes polyploidy that is suggestive of inaptitude for cytokinesis. "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/1993 - "Bistramide A, a new toxin isolated from a New Caledonian Urochordata, shows an antiproliferative effect on a non-small-cell lung carcinoma line in vitro and G1-blockade. " 06/02/2010 - "We describe structure-based design and chemical synthesis of a simplified analog of bistramide A, which potently and reversibly binds monomeric actin with a K(d) of 9.0 nM, depolymerizes filamentous actin in vitro and in A549 (nonsmall cell lung cancer) cells, inhibits growth of cancer cell lines in vitro at submicromolar concentrations, and significantly suppresses proliferation of A549 cells in a nude mice tumor xenograft model in terms of both tumor growth delay and average tumor volume. "
5.	Paresthesia (Dysesthesia) 01/01/1988 - "Preliminary toxicological investigations indicate that bistramide A may effect the central nervous system, leading to paresthesia and loss of muscle tone. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein Kinase C
3.	Isoenzymes
4.	Acetates (Acetic Acid Esters)
5.	westiellamide
6.	bisindolylmaleimide I
7.	phorbol
8.	ingenol