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isoglutamine

RN given refers to cpd without isomeric designation; structure given in first source
Also Known As:
4,5-diamino-5-oxopentanoic acid; isoglutamine, (+-)-isomer; isoglutamine, (L)-isomer
Networked: 26 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Nicholson, Jeremy K: 2 articles (06/2014 - 02/2013)
2. Goldin, Robert D: 2 articles (06/2014 - 02/2013)
3. Jiménez, Beatriz: 2 articles (06/2014 - 02/2013)
4. Darzi, Ara: 2 articles (06/2014 - 02/2013)
5. Holmes, Elaine: 2 articles (06/2014 - 02/2013)
6. Mirnezami, Reza: 2 articles (06/2014 - 02/2013)
7. Veselkov, Kirill: 1 article (06/2014)
8. Kinross, James M: 1 article (06/2014)
9. Li, Jia V: 1 article (06/2014)
10. Ziprin, Paul: 1 article (02/2013)

Related Diseases

1. Infection
12/01/1984 - "[Mechanism of action of N-acetylglucosaminyl-N-acetylmuramylalanyl-D-isoglutamine on the nonspecific anti-infection resistance of mice]."
01/01/1992 - "Another analogue of N-acetylmuramyl-D-isoglutamine (MDP), N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine [MDP-Lys(L18)], which has been shown to enhance non-specific protective activity against bacterial and viral infections, however, showed no adjuvant activity in the present system. "
12/01/1985 - "The efficacy of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), 6-O-stearoyl-MDP (L18-MDP), N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine (MDP-Lys-L18) and N-stearoylmuramyl-L-alanyl-D-isoglutamine (2N-L18-MDP) for augmenting host-resistance to viral infection was examined in Sendai virus infected mice. "
01/01/1989 - "Immunostimulatory effects of 1-O-acylated derivatives of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP) methyl ester, with or without the 6-O-phosphoryl group, on augmentation of IgG antibody response against influenza hemagglutinin (HA) vaccine, in vivo macrophage activation and enhancement of non-specific host resistance against Pseudomonas aeruginosa infection were investigated. "
05/01/1981 - "The experimental system utilized in investigating the correlation between the chemical structures of muramyl peptides and their protective activities in the sepsis type of systemic infections caused by Escherichia coli was applied in evaluating the enhancement of resistance to infection induced by 32 synthetic glycopeptide analogs, including 6-O-acyl derivatives and 1-alpha-O-benzyl derivatives of muramyl dipeptide (N-acetyl muramyl-L-alanyl-D-isoglutamine). "
2. Lewis Lung Carcinoma
3. Neoplasms (Cancer)
07/01/1984 - "Activation of peritoneal exudate macrophages of mice to inhibit the in vitro proliferation of tumor target cells was achieved with low concentrations of N-acetyl-L-alanyl-D-isoglutamine (MDP for muramyl dipeptide) conjugated to a synthetic carrier. "
06/01/2002 - "N-Phthalyl isoglutamine, having the substitution at position 1 of the glutamic acid moiety, is the metabolite of recently approved thalidomide for different types of tumors by US FDA. "
01/01/1981 - "N-Acetyl muramyl-L-valyl-D-isoglutamine (MurNac-L-Val-D-isoGln), QS-10-MurNAc-L-Val-D-isoGln, and their methyl esters were shown to have potent adjuvant activity on the induction of delayed-type hypersensitivity to monoazobenzenarsonate-N-acetyl-L-tyrosine in guinea pigs and on the primary immune response against sheep erythrocytes in vitro; however, only QS-10-MurNAc-L-Val-D-isoGln methyl ester, i.e., QS-10-MurNAc-L-Val-D-Glu(OCH3)NH2 (quinonyl-MDP-66), was shown to be an active adjuvant for the induction of allogeneic killer T cells in mice and the suppression of tumor growth in syngeneic mice when it was administered as a suspension in phosphate-buffered saline. "
06/01/2014 - "Cancer tissue contained significantly increased levels of lactate (P < 0.005), taurine (P < 0.005), and isoglutamine (P < 0.005) and decreased levels of lipids/triglycerides (P < 0.005) relative to healthy mucosa (R2Y = 0.94; Q2Y = 0.72; area under the curve, 0.98). "
08/01/1989 - "Liposomes' uses in cancer therapy include encapsulation of known antineoplastic agents such as doxorubicin and methotrexate, delivery of immune modulators such as N-acetylmuramyl-L-alanine-D-isoglutamine, and encapsulation of new chemical entities that are synthesized with lipophilic segments tailored for insertion into lipid bilayers. "
4. Hypersensitivity (Allergy)
5. Arthritis (Polyarthritis)

Related Drugs and Biologics

1. Acetylmuramyl-Alanyl-Isoglutamine
2. Lysine (L-Lysine)
3. Lactic Acid
4. Triglycerides (Triacylglycerol)
5. Taurine
6. Peptidoglycan (Murein)
7. Lipids
8. Alanine (L-Alanine)
9. Fumigant 93 (D-D)
10. Glutamic Acid (Glutamate)