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SPan-1 pancreatic associated antigen
Also Known As:
pancreatic associated antigen, SPan-1; SPan-1 antigen
Networked:
11
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Biological Factors: 2472
Antigens: 143924
Neoplasm Antigens: 6217
SPan-1 pancreatic associated antigen: 11
Related Diseases
1.
Pancreatic Neoplasms (Pancreatic Cancer)
04/01/1991 - "
We studied SPan-1 antigen in 64 patients with pancreatic cancer by measuring serum concentrations with RIABEAD and examining the intratumor staining patterns immunohistochemically.
"
04/01/1991 - "
Serum concentration and immunohistochemical localization of SPan-1 antigen in pancreatic cancer.
"
02/01/1990 - "
These results suggest that determination of serum SPan-1 antigen levels by this assay kit is useful for the diagnosis and monitoring of pancreatic cancer.
"
02/01/1990 - "
SPan-1 antigen levels in cultured medium of four out of five pancreatic cancer cell lines showed more than 1000 units/ml by this assay.
"
04/01/1989 - "
From these results, measurement of SPan-1 antigen appeared to be the most useful marker in the diagnosis of pancreatic cancer.
"
2.
Neoplasms (Cancer)
01/01/1996 - "
The serum SPan-1 antigen level was elevated to 250 U/ml, and the serum CA19-9 level was also elevated to 580 U/ml. Since urological malignancy was not excluded from these findings, left nephroureterectomy was performed.
"
06/01/1993 - "
SPan-1 antigen levels were elevated in 89.2% of sera from pancreatic cancer patients and in 75% of T1 and T2 cancers.
"
11/11/1992 - "
SPan-1 antigen was elevated in a high percentage of patients with pancreatic, gastric and colorectal cancer but in only a few of the patients with malignancies of non-GI origin such as breast, ovary and lung.
"
07/01/1992 - "
These findings suggest that molecular size heterogeneity of SPan-1 antigen was more often in pancreatic cancer cells and overexpression of SPan-1 epitope on the same molecule seems to be specific for cancer.
"
07/01/1992 - "
Molecular size of SPan-1 antigen and co-expression between SPan-1 epitope and Lewis phenotype determinants (LPD) on the same molecule in sera from patients with pancreatic, gastric and colon cancer and in culture medium from cancer cell line were studied.
"
3.
Colonic Neoplasms (Colon Cancer)
05/01/1995 - "
Role of SPan-1 antigen in adhesion of human colon cancer cells to vascular endothelium.
"
07/01/1992 - "
Molecular size of SPan-1 antigen and co-expression between SPan-1 epitope and Lewis phenotype determinants (LPD) on the same molecule in sera from patients with pancreatic, gastric and colon cancer and in culture medium from cancer cell line were studied.
"
05/01/1995 - "
These findings suggest that the SPan-1 antigen plays a significant role in the adhesion of human colon cancer cells to endothelial cells, and sialylation of the terminal structure of carbohydrate antigens is important in this adhesion.
"
02/01/1990 - "
While over 90% of pancreatic cancer patients had elevated levels of serum SPan-1 antigen, only 0-17% of patients with other malignant and non malignant gastrointestinal diseases such as pancreatitis (chronic or acute), gastric cancer or colon cancer had above normal levels.
"
4.
Pancreatic Diseases (Pancreatic Disease)
04/01/1990 - "
We studied clinical significance of serum SPan-1 antigen, which is human pancreatic cancer associated antigen, in hepatobiliary and pancreatic diseases employing newly developed kit.
"
04/01/1989 - "
False positive ratio of SPan-1 antigen in benign pancreatic disease was lower than that of CA 19-9. Also, comparative studies of SPan-1 antigen and various tumor markers between pancreatic cancer and benign gastrointestinal diseases revealed that SPan-1 antigen showed the highest sensitivity and accuracy in diagnosis for pancreatic cancer among other tumor markers.
"
5.
Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
04/01/1989 - "
False positive ratio of SPan-1 antigen in benign pancreatic disease was lower than that of CA 19-9. Also, comparative studies of SPan-1 antigen and various tumor markers between pancreatic cancer and benign gastrointestinal diseases revealed that SPan-1 antigen showed the highest sensitivity and accuracy in diagnosis for pancreatic cancer among other tumor markers.
"
02/01/1990 - "
While over 90% of pancreatic cancer patients had elevated levels of serum SPan-1 antigen, only 0-17% of patients with other malignant and non malignant gastrointestinal diseases such as pancreatitis (chronic or acute), gastric cancer or colon cancer had above normal levels.
"
Related Drugs and Biologics
1.
Tumor Biomarkers (Tumor Markers)
2.
Antigens
3.
Pancreatic Elastase (Elastase)
4.
Mucins
5.
Carbohydrates
6.
Epitopes
7.
Monoclonal Antibodies
Related Therapies and Procedures
1.
Nephroureterectomy