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Fluo-3

fluorescent Ca(2+) indicator; permits continuous monitoring of Ca without interference with use of UV-sensitive caged compounds
Also Known As:
Fluo 3; fluo-3-AM
Networked: 60 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Lang, Florian: 9 articles (01/2015 - 10/2011)
2. Jilani, Kashif: 7 articles (05/2014 - 10/2011)
3. Lupescu, Adrian: 6 articles (05/2014 - 01/2012)
4. Zbidah, Mohanad: 5 articles (12/2012 - 01/2012)
5. Shaik, Nazneen: 4 articles (12/2012 - 01/2012)
6. Lang, Elisabeth: 3 articles (11/2012 - 10/2011)
7. Zelenak, Christine: 3 articles (01/2012 - 10/2011)
8. Bissinger, Rosi: 2 articles (05/2014 - 07/2013)
9. Abed, Majed: 2 articles (07/2013 - 10/2011)
10. Liu, Ya: 2 articles (05/2013 - 01/2011)

Related Diseases

1. Herpes Zoster
2. Neuroblastoma
3. Contracture
11/15/1994 - "1. The calcium-sensitive dye fluo-3 AM was used to obtain fluorescence signals and calcium transients associated with K+ contractures, twitches and tetani, in intact single muscle fibres of the tropical toad Leptodactylus insularis. "
11/15/1994 - "Fluo-3 signals associated with potassium contractures in single amphibian muscle fibres."
05/01/2001 - "Rapid cooling contracture experiments and experiments measuring fluorescence of myocytes loaded with 5 microM Fluo-3 AM dye demonstrated that the hyperthermia-induced rise in resting tension was likely due to an increase in intracellular calcium content. "
05/01/2001 - "Inhibition of the sarcoplasmic reticulum calcium pump with 20 microM thapsigargin resulted in irreversible contracture of the papillary muscles at temperatures between 45 degrees and 50 degrees C and significant increases in Fluo-3 fluorescence at 48 degrees C. "
11/01/2000 - "To study the regulation of [Na+]i and [Ca2+]i during myocardial ischemia/reperfusion, [Na+]i and [Ca2+]i were measured simultaneously using guinea pig ventricular myocytes which were dual-loaded with SBFI/AM and fluo-3/AM. It was suggested that: (1) [Na+]i increased during metabolic inhibition (MI: 3.3 mM amytal and 5 microM CCCP) by both the activated Na+ influx via Na+/H+ exchange and the suppressed Na+ extrusion via the Na+/K+ pump; (2) Na+/Ca2+ exchange was inhibited during MI, causing the dissociation between [Na+]i and [Ca2+]i; (3) Na+/Ca2+ exchange could be reactivated by energy repletion, resulting in a significant increase in [Ca2+], Furthermore, a Ca2+ influx via the reverse-mode of Na+/Ca2+ exchange may play a key role in the mechanism of Ca2+ overload on reoxygenation; and (4) cell contracture during MI was related to rigor due to energy depletion, while cell contracture after energy repletion was likely to be related to Ca2+ overload."
4. Carcinoma (Carcinomatosis)
5. Myocardial Ischemia (Ischemic Heart Diseases)

Related Drugs and Biologics

1. Calcium
2. PAR-1 Receptor
3. Thrombin Receptors (Thrombin Receptor)
4. Thrombin
5. Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)
6. Amobarbital (Amsal)
7. sodium binding benzofuran isophthalate acetoxymethyl ester
8. thrombin receptor peptide SFLLRNP
9. thrombin receptor peptide (42-47)
10. Annexin A5

Related Therapies and Procedures

1. Lasers (Laser)
2. Ligation
3. Induced Hyperthermia (Thermotherapy)