|1.||Oredsson, Stina M: 9 articles (02/2012 - 02/2002)|
|2.||Alm, Kersti: 7 articles (02/2012 - 07/2003)|
|3.||Zhang, Wei: 4 articles (04/2012 - 02/2005)|
|4.||Kramer, Debora L: 4 articles (02/2011 - 07/2003)|
|5.||Porter, Carl W: 4 articles (02/2011 - 07/2003)|
|6.||Holst, C Martina: 4 articles (11/2010 - 04/2005)|
|7.||Casero, Robert A: 4 articles (08/2004 - 03/2002)|
|8.||Alhonen, Leena: 3 articles (02/2012 - 02/2002)|
|9.||Johansson, Veronica M: 3 articles (02/2012 - 01/2008)|
|10.||Diegelman, Paula: 3 articles (02/2011 - 07/2003)|
08/01/2004 - "The polyamine analogue, N1, N11-diethylnorspermine (DENSpm), is currently being evaluated in clinical trials for the treatment of solid tumors. "
01/01/1997 - "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i.v. infusion every 12 h for 5 days (10 doses). "
08/01/2004 - "Immunohistochemical staining for induction of SSAT correlates with measures of enzymatic activity in a small sample where measurements were possible and suggests that immunohistochemistry may be used for predicting response of breast cancers to DENSpm. "
08/01/2004 - "SSAT expression was significantly increased in 30 of 38 tumor samples treated with DENSpm compared to untreated controls. "
08/01/2002 - "Several polyamine analogues are currently being developed for clinical application against human solid tumors including N1,N11-bis(ethyl)norspermine. "
|2.||Melanoma (Melanoma, Malignant)
08/07/2003 - "Among the melanoma cell lines (SK-MEL-28, MALME-3M, A375 and LOX), survivin degradation correlated temporally with the onset of DENSPM induced apoptosis or growth inhibition. "
07/01/2003 - "The generality of this effect was demonstrated in DENSPM-treated A375 and LOX human melanoma cells. "
09/01/2001 - "Here, we characterize the polyamine effects and apoptotic signaling events initiated by treatment of SK-MEL-28 human melanoma with 10 microM DENSPM. "
07/01/1997 - "The relative ability of a series of eight systematically modified DE-333 analogs to affect SSAT expression was examined in Malme-3M human melanoma cells, one of several cell lines known to be especially responsive to induction of this enzyme. "
11/15/1994 - "The collateral sensitivity of human melanoma MDR variants to DENSPM represents a possible therapeutic indication which should be considered during the ongoing clinical evaluation of this drug."
09/01/2000 - "In vitro studies showed that all four tested human prostate carcinoma cell lines were sensitive to DENSpm in micromolar concentrations. "
09/01/2000 - "In this study, the in vitro and in vivo antitumor potential of the polyamine analog N(1), N(11)-diethylnorspermine (DENSpm) in human prostate carcinoma cells was examined. "
08/01/1995 - "In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0.1 and 1 micrometer the only exception was the HT29 colon carcinoma cell line, which had an IC50 of >100 micrometer. "
09/01/2000 - "DENSpm has sustained inhibitory effects on the growth of human prostate carcinoma cells in vitro as well in vivo. "
08/01/1995 - "However, in similarity to in vitro findings, HT29 colon carcinoma xenografts responded poorly to DENSPM treatment. "
|4.||Breast Neoplasms (Breast Cancer)
04/01/2008 - "To better understand under what circumstances treatment with a polyamine analogue will yield beneficial results, we have investigated the effect of N,N-diethylnorspermine (DENSPM) on cell cycle kinetics of the human breast cancer cell lines SK-BR-3, MCF-7, HCC1937, and L56Br-C1. "
12/01/2003 - "This study evaluated the activity of the first-generation analog DENSpm in women with metastatic breast cancer. "
12/01/2003 - "A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer."
04/01/2009 - "We also show that MCF-10A cells rapidly recover from DENSPM-induced growth inhibition in contrast to four human breast cancer cell lines. "
04/01/2009 - "The ability of both normal-like and breast cancer cells to recover from DENSPM treatment was also studied. "
|3.||Adenocarcinoma of lung
|8.||Protein Kinases (Protein Kinase)
|1.||Heterologous Transplantation (Xenotransplantation)
|4.||Drug Therapy (Chemotherapy)