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onnamide
structure given in first source; isolated from marine sponges
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Lactones: 1549
Polyketides: 231
Polyether Polyketides: 22
Polyether Toxins: 28
onnamide: 1
Ethers: 242
Cyclic Ethers: 12
Polyether Polyketides: 22
Polyether Toxins: 28
onnamide: 1
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Polyketides: 231
Polyether Polyketides: 22
Polyether Toxins: 28
onnamide: 1
Cyclic Ethers: 12
Polyether Polyketides: 22
Polyether Toxins: 28
onnamide: 1
Biological Factors: 2472
Biological Toxins: 20
Marine Toxins: 124
Polyether Toxins: 28
onnamide: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
onnamide: 1
Related Diseases
1.
Neoplasms (Cancer)
06/01/1989 - "
Mycalamide-A and -B were also potent inhibitors of HL-60, HT-29, and A549 human tumor cell replication (50% inhibitory concentration less than 5 nM), while values for onnamide were greater (50% inhibitory concentrations between 25 and 200 nM).
"
2.
Leukemia P388
06/01/1989 - "
Mycalamide-A (10 micrograms/kg) and -B (2.5 micrograms/kg) were moderately active against P388 leukemia (increase in life span, approximately 50%), while onnamide was inactive (40 micrograms/kg; increase in life span, 15%).
"
Related Drugs and Biologics
1.
mycalamide A