structure given in first source; RN given refers to (2R-(2alpha,2(S*(S*)),5beta,6beta))-isomer; isolated from marine sponges
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Bio-Agent Context: Research Results
|1. ||Neoplasms (Cancer)
- "Here, for the first time, we report the isolation of mycalamide A from ascidian Polysincraton sp. as well as investigation of its cancer preventive properties.
- "Mycalamide-A and -B were also potent inhibitors of HL-60, HT-29, and A549 human tumor cell replication (50% inhibitory concentration less than 5 nM), while values for onnamide were greater (50% inhibitory concentrations between 25 and 200 nM).
- "Mycalamide-A was also active against B16 melanoma, Lewis lung carcinoma, M5076 ovarian sarcoma, colon 26 carcinoma, and the human MX-1, CX-1, and Burkitt's lymphoma tumor xenografts.
|2. ||Lewis Lung Carcinoma
|3. ||Sarcoma (Soft Tissue Sarcoma)
|4. ||Experimental Melanoma
|5. ||Leukemia P388
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