HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2- formyl- 5- (hydroxymethyl)pyrrole- 1- norleucine

formed by Maillard recaction of bovine serum albumin with glucose; RN refers to (S)-isomer

Also Known As:

2-FHMPN; 2-amino-6-(2-formyl-5-hydroxymethylpyrrol-1-yl)hexanoic acid; pyrraline

Networked: 20 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminocaproates: 1
    - Norleucine: 30
      - 2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine: 20
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine: 20

Experts

1.	Nagai, R: 4 articles (01/2007 - 03/2000)
2.	Horiuchi, S: 3 articles (02/2001 - 03/2000)
3.	Jono, T: 3 articles (02/2001 - 03/2000)
4.	Li, Bing: 2 articles (10/2016 - 07/2016)
5.	Li, Lin: 2 articles (10/2016 - 07/2016)
6.	Liang, Zhili: 2 articles (10/2016 - 07/2016)
7.	Qi, Haiping: 2 articles (10/2016 - 07/2016)
8.	Yoshihara, Kazuhiro: 2 articles (08/2004 - 09/2003)
9.	Sakata, N: 2 articles (02/2001 - 03/2000)
10.	Takebayashi, S: 2 articles (02/2001 - 03/2000)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 02/01/2003 - "Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes." 02/01/2003 - "This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. " 08/01/2004 - "To determine factors that influence the urinary excretion of pyrraline or pentosidine, we compared pyrraline or pentosidine concentrations with glycemic-control indexes, urinary albumin excretion, and urinary beta2-microglobulin in patients with type 2 diabetes. "
2.	Amyloid Plaque 06/07/1994 - "Specifically, antibodies against two Maillard end products, pyrraline and pentosidine, immunocytochemically label neurofibrillary tangles and senile plaques in brain tissue from patients with Alzheimer disease. " 03/01/2000 - "Renal specimens from 19 cases of AA amyloidosis and 14 cases of AL amyloidosis were investigated for immunolocalization of CML, pyrraline, collagen type IV and laminin in amyloid deposits. "
3.	Chronic Kidney Failure (Chronic Renal Failure) 07/05/1996 - "To elucidate the involvement of pyrraline in uremia, we examined the pyrraline levels in patients with chronic renal failure by a mass spectrometric approach. " 08/01/1999 - "pentosidine, carboxymethyllysine, pyrraline or imidazolone, but a systematic assessment of known compounds using specific HPLC methods in diabetic and non-diabetic end-stage renal disease (ESRD) patients during treatment has not been performed. "
4.	Diabetic Nephropathies (Diabetic Nephropathy) 08/01/2004 - "Because urinary pyrraline is more directly influenced by glycemia than by pentosidine, the difference in glycemic control among diabetic patients with various grades of nephropathy may be responsible for a dissociation between urinary pyrraline and pentosidine concentrations in patients with overt diabetic nephropathy." 12/15/1997 - "To assess the possible link between AGE accumulation and the development of diabetic nephropathy (DN), we have examined the immunohistochemical localization of various AGE structures postulated to date, i.e., pentosidine, Nepsilon-(carboxymethyl)lysine (CML), and pyrraline, in diabetic and control kidneys. "
5.	Alzheimer Disease (Alzheimer's Disease) 05/01/1997 - "Furthermore, involvement of the Maillard reaction with Alzheimer's disease has also been suggested, as advanced glycation end products, such as pyrraline and pentosidine, were demonstrated to localize in lesions of the disease. " 06/07/1994 - "Specifically, antibodies against two Maillard end products, pyrraline and pentosidine, immunocytochemically label neurofibrillary tangles and senile plaques in brain tissue from patients with Alzheimer disease. "

Related Drugs and Biologics

1.	pentosidine
2.	Acrolein (Aqualin)
3.	Advanced Glycation End Products
4.	Lysine (L-Lysine)
5.	imidazolone
6.	Indicators and Reagents (Reagents)
7.	Albumins
8.	N(6)-carboxymethyllysine (carboxymethyllysine)
9.	Heme Oxygenase-1
10.	Collagen Type IV (Type IV Collagen)

Related Therapies and Procedures

1.	Glycemic Control