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deltorphin

isolated from skin of Phyllomedusa sauvagei; has affinity to opioid receptor; note deltorphin I and deltorphin II are available, they have Ala in position 2
Also Known As:
Tyr-Met-Phe-His-Leu-Met-Asp-NH2; dermenkephalin; tyrosyl-methionyl-phenylalanyl-histidyl-leucyl-methionyl-aspartamide
Networked: 22 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Oeltgen, Peter R: 3 articles (01/2014 - 02/2006)
2. Govindaswami, Meera: 3 articles (03/2008 - 02/2006)
3. Oeltgen, Peter: 3 articles (01/2008 - 05/2004)
4. Capasso, Anna: 2 articles (03/2009 - 02/2002)
5. Sonneborn, Joan Smith: 2 articles (01/2008 - 05/2004)
6. Wang, Chunyan: 1 article (01/2015)
7. Wang, Guolin: 1 article (01/2015)
8. Yu, Yonghao: 1 article (01/2015)
9. Zhang, Linlin: 1 article (01/2015)
10. Shu, Ruichen: 1 article (01/2015)

Related Diseases

1. Hypoglycemia (Reactive Hypoglycemia)
2. Wounds and Injuries (Trauma)
3. Hyperphagia
4. Ischemia
03/01/2008 - "The authors present evidence that the delta opioid receptor agonist Deltorphin-D(variant) (Delt-D(var)) and hibernating woodchuck plasma (HWP), but not summer-active woodchuck plasma (SAWP), can provide significant neuroprotection from focal ischemia in mice by a mechanism that relies in part on reducing nitric oxide (NO) release in ischemic tissue. "
11/01/2005 - "In contrast, the pretreatment with the selective delta2-OR agonist deltorphin II (0.12 mg/kg) and the proposed delta2-OR agonists deltorphin D (0.3 mg/kg) and/or dermorphin H (0.23 mg/kg) increases cardiac resistance to the arrhythmogenic action of acute ischemia and reperfusion. "
05/01/2004 - "Serum from hibernating woodchucks (hibernation induction trigger [HIT]), from summer nonhibernating animals (summer woodchuck active plasma [SWAP], and potential "hibernation opioid mimics" (D-Ala(2) D Leu(5) Enkephalin [DADLE]), and Deltorphin D (Delt D) were used as ischemic preconditioning agents (IPC) in an in vivo surgically induced cardiac ischemia rat model. "
01/01/2014 - "Anesthetized open-chest male Wistar rats were subjected to either 45 minutes of left coronary artery occlusion (phase 1a 10 minutes and phase 2b 35 minutes) and 2 hours of reperfusion in Experiment 1 or 10 minutes of ischemia and 10 minutes of reperfusion in Experiment 2. In Experiment 1, saline or vehicle controls and the mu-specific opioids dermorphin-H (Derm-H) and ([d-Ala2, N-Me-Phe4, Gly-ol5] enkephalin (DAMAGO); the delta-1-specific opioid d-Pen2,5enkephalin (DPDPE); nociceptin; and the delta-2-specific opioids deltorphin-II (Delt-II), Delt-Dvariant (Delt-Dvar), and deltorphin-E (Delt-E) were infused 15 minutes prior to ischemia. "
5. Contracture

Related Drugs and Biologics

1. delta Opioid Receptors (delta Opioid Receptor)
2. Ala(2)- deltorphin II
3. Enkephalins
4. D-Penicillamine (2,5)- Enkephalin
5. Insulin (Novolin)
6. naltrindole
7. Opioid Receptors (Opioid Receptor)
8. Narcotic Antagonists (Opioid Antagonists)
9. Naltrexone (ReVia)
10. Ala(2)-Cys(6)- enkephalin-Leu

Related Therapies and Procedures

1. Injections
2. Analgesia
3. Aftercare (After-Treatment)