|1.||Schubert, Uwe: 1 article (04/2006)|
|2.||Alt, Alex: 1 article (04/2006)|
|3.||Schleicher, Erwin: 1 article (04/2006)|
|4.||Preissner, Klaus T: 1 article (04/2006)|
|5.||Lochnit, Günther: 1 article (04/2006)|
|6.||Hammes, Hans-Peter: 1 article (04/2006)|
|7.||Hoffmann, Jennifer: 1 article (04/2006)|
|8.||Lin, Jihong: 1 article (04/2006)|
|9.||Van der Woude, Fokko J: 1 article (04/2006)|
|10.||Brownlee, Michael: 1 article (04/2006)|
|1.||Alzheimer Disease (Alzheimer's Disease)
02/27/1997 - "These experimental data, and clinical studies, reporting a marked improvement in cognition and memory in Alzheimer's disease patients after Tenilsetam treatment, suggest that AGEs might play an important role in the etiology or progression of the disease. "
01/01/1994 - "A beneficial effect of Tenilsetam in Alzheimer's disease could come from the interference with AGE-derived crosslinking of amyloid plaques and a decreased inflammatory response by diminished activation of phagocytosing microglia."
01/01/1994 - "Tenilsetam (CAS 997: (+/-)-3-(2-thienyl)-2-piperazinone), a cognition-enhancing drug successfully used for treatment of patients suffering from Alzheimer's disease, when included in the Maillard reaction apparently inhibits protein crosslinking by AGEs in vitro. "
|2.||Diabetic Retinopathy (Retinopathy, Diabetic)
04/01/2006 - "These data suggest that, independent of known properties, tenilsetam shows important rescue functions on endothelial cells which could be useful for the treatment of early diabetic retinopathy."
04/01/2006 - "Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss."
01/01/2005 - "In our study, extracellularly applied methylglyoxal was shown to be toxic to human neuroblastoma cells in a dose-dependent manner above concentrations of 150 microM with a LD50 of approximately 1.25 mM. Pre-incubation of methylglyoxal with a variety of carbonyl scavengers such as aminoguanidine or tenilsetam and the thiol antioxidant lipoic acid significantly reduced its toxicity. "
|3.||Thioctic Acid (Lipoic Acid)
|7.||Monoamine Oxidase (MAO)