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S 312

structure given in first source
Also Known As:
S-312; S-312-d; methyl 4,7-dihydro-3-isobutyl-6-methyl-4-(nitrophenyl)thieno(2,3-b)-pyridine-5-carboxylate; Thieno(2,3-b)pyridine-5-carboxylic acid, 4,7-dihydro-6-methyl-3-(2-methylpropyl)-4-(3-nitrophenyl)-, methyl ester, (+-)-
Networked: 6 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Amano, Taku: 1 article (07/2004)
2. Sakai, Norio: 1 article (07/2004)
3. Serikawa, Tadao: 1 article (07/2004)
4. Seki, Takahiro: 1 article (07/2004)
5. Matsubayashi, Hiroaki: 1 article (07/2004)
6. Sasa, Masashi: 1 article (07/2004)
7. Aihua, Zhu: 1 article (07/2004)

Related Diseases

1. Ischemia
2. Hypertension (High Blood Pressure)
3. Body Weight (Weight, Body)
4. Stroke (Strokes)
12/01/1993 - "Histological examination of the brain of SHRSP showed that the arbitrary neurotoxic index (ANI) for stroke lesion dose-dependently decreased with S-312-d at 1, 3, and 10 mg/kg as follows: 4.8, 3.0, 2.3. "
12/01/1993 - "The therapeutic effects of nicardipine (ANI 3.9) at 10 mg/kg corresponded to those of S-312-d at 3 mg/kg. Thus, S-312-d can be recommended for the treatment of cerebral insufficiency or vasospasm following stroke as well as in essential hypertension."
12/01/1993 - "The prophylactic and therapeutic effects of S-312-d (S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate, CAS 120056-57-7) were compared with those of nimodipine or nicardipine using male stroke-prone spontaneously hypertensive rats (SHRSP). "
12/01/1993 - "Hypotensive and antihypertensive effects of S-312-d (S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate, CAS 120056-57-7) in Wistar Kyoto rat (WKY), spontaneously hypertensive rat (SHR), stroke-prone SHR (SHRSP), and DOCA-salt hypertensive rat (DOCA-HR) were compared with those of other representative calcium antagonists. "
12/01/1993 - "Moderate diuretic effects were observed with S-312-d at doses of 1 and 3 mg/kg. The appearance of urinary occult blood in control SHRSP was markedly inhibited with S-312-d at 1 mg/kg and nimodipine at 10 mg/kg. Histological examination of the brain of SHRSP showed that cerebral stroke lesion including edema, hemorrhage, and/or softening was dose-dependently inhibited with S-312-d. "
5. Seizures (Seizure)

Related Drugs and Biologics

1. benzocycloheptapyridine
2. Calcium
3. S 312
4. L-Type Calcium Channels (Dihydropyridine Receptor)
5. Glutamic Acid (Glutamate)
6. N-Methylaspartate (NMDA)
7. Calcium Channels (Calcium Channel)
8. Taurine
9. Picrotoxin
10. Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1. Oral Administration