Shelterin Complex

A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).

Also Known As:

Capping Complex, Telomeric; Complex, CST; Complex, Ctc1-Stn1-Ten1; Complex, POT1-TPP1 Shelterin; Complex, Shelterin; Complex, Telomere POT1-TPP1; Complex, Telomeric Capping; Ctc1 Stn1 Ten1 Complex; POT1 TPP1 Shelterin Complex; POT1-TPP1 Complex, Telomere; Shelterin Complex, POT1-TPP1; Telomere POT1 TPP1 Complex; Telomeric Stn1 Ten1 Capping Complex; Telosomes; CST Complex; Ctc1-Stn1-Ten1 Complex; POT1-TPP1 Shelterin Complex; Telomere Cap Complex; Telomere POT1-TPP1 Complex; Telomeric Capping Complex; Telomeric Stn1-Ten1 Capping Complex; Telosome

Cells
- Cellular Structures
  - Intracellular Space
    - Cell Nucleus
      - Cell Nucleus Structures
        Intranuclear Space
        Chromosomes
        Chromosome Structures
        Telomere
        Shelterin Complex: 70
Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Shelterin Complex: 70
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nuclear Proteins: 2678
    - Non-Histone Chromosomal Proteins: 44
      - Telomere-Binding Proteins: 74
        Shelterin Complex: 70
  - DNA-Binding Proteins: 2009
    - Telomere-Binding Proteins: 74
      - Shelterin Complex: 70
  - Nucleoproteins: 1870
    - Shelterin Complex: 70
Genetic Phenomena
- Genetic Structures
  - Chromosome Structures
    - Telomere
      - Shelterin Complex: 70

1.	Male Infertility (Male Sterility) 03/30/2023 - "In silico exploration and molecular dynamics of deleterious SNPs on the human TERF1 protein triggering male infertility."

human TERF1 protein

Bio-Agent Context: Research Results

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