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sinensetin

isolated from citrus fruit; exhibit antiadhesive action on platelets

Also Known As:

3',4',5,6,7-pentamethoxyflavone

Networked: 32 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        sinensetin: 32
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        sinensetin: 32

Experts

1.	Ha, Sang Eun: 3 articles (05/2021 - 10/2019)
2.	Kim, Gon Sup: 3 articles (05/2021 - 10/2019)
3.	Kim, Seong Min: 3 articles (05/2021 - 10/2019)
4.	Vetrivel, Preethi: 3 articles (05/2021 - 10/2019)
5.	Kim, Hun Hwan: 2 articles (05/2021 - 08/2020)
6.	Lee, Keun Woo: 2 articles (05/2021 - 08/2020)
7.	Rampogu, Shailima: 2 articles (05/2021 - 08/2020)
8.	Kang, Seong-Il: 2 articles (01/2013 - 01/2012)
9.	Kim, Se-Jae: 2 articles (01/2013 - 01/2012)
10.	Ko, Hee-Chul: 2 articles (01/2013 - 01/2012)

Related Diseases

1.	Osteoarthritis 10/03/2022 - "Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3." 01/01/2021 - "Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway."
2.	Diabetic Nephropathies (Diabetic Nephropathy) 10/01/2023 - "Sinensetin ameliorates high glucose-induced diabetic nephropathy via enhancing autophagy in vitro and in vivo."
3.	Adenocarcinoma 03/01/2020 - "In conclusion, the current study indicated that Sinensetin flavone has the potential to be developed as a candidate drug against gallbladder adenocarcinoma provided more toxicological and in vivo studies are carried out." 03/01/2020 - "Sinensetin flavone exhibits potent anticancer activity against drug-resistant human gallbladder adenocarcinoma cells by targeting PTEN/PI3K/AKT signalling pathway, induces cellular apoptosis and inhibits cell migration and invasion." 03/01/2020 - "The main focus of the current research work was to unveil the anticancer activity of the naturally occurring Sinensetin flavone against aggressive gall bladder cancer adenocarcinoma (GBAC) TJ-GBC2 cell line. " 10/29/2009 - "In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative activity in MDA-MB-468 human breast adenocarcinoma and MCF-10A normal breast cell lines, were investigated. "
4.	Obesity 01/01/2013 - "Taken together, these results suggest that sinensetin may have potential as a natural agent for prevention/improvement of obesity." 01/01/2020 - "In-vitro and in-vivo studies showed that sinensetin possessed strong anticancer activities and a wide range of pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, anti-obesity, anti-dementia and vasorelaxant activities. " 06/07/2023 - "Furthermore, sinensetin was reported to have the beneficial effect of ameliorating metabolic syndromes, including disorders of lipid metabolism (obesity, NAFLD, atherosclerosis), glucose metabolism disorder (insulin resistant) and inflammation, in terms of improving the composition of intestinal flora and modulating metabolic pathway factors in relevant tissues. " 12/07/2022 - "Scientific data analysis signified the biological importance of sinensetin against tumors, gastric cancer, colorectal cancer, breast cancer, diabetes, influenza H1N1 infection, obesity, inflammation, colitis, brain disorders, and microbial infections. "
5.	Colorectal Neoplasms (Colorectal Cancer) 02/02/2019 - "In this study, we evaluated the effect of an orange peel extract (OPE) and its main PMFs, namely, nobiletin, sinensetin, tangeretin, and scutellarein tetramethylether in targeting cell proliferation and stemness using a 3D cell model of colorectal cancer composed of HT29 cell spheroids cultured for 7 days in stirred conditions. " 12/07/2022 - "Scientific data analysis signified the biological importance of sinensetin against tumors, gastric cancer, colorectal cancer, breast cancer, diabetes, influenza H1N1 infection, obesity, inflammation, colitis, brain disorders, and microbial infections. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Flavonoids
3.	scutellarein
4.	Antioxidants
5.	Catenins
6.	Cytochrome P-450 CYP1A2 (CYP1A2)
7.	Cytochrome P-450 CYP1A1 (CYP1A1)
8.	Vasodilator Agents (Vasodilators)
9.	Glycogen Synthase (Synthase I)
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Low-Level Light Therapy (LLLT)