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3,3',4',5,6,7,8-heptamethoxyflavone

has anti-inflammatory activity; isolated from citrus fruit; exhibit antiadhesive action on platelets

Also Known As:

3,5,6,7,8,3',4'-heptamethoxyflavone; 3-HPTMF; HEPTA-3

Networked: 11 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        3,3',4',5,6,7,8-heptamethoxyflavone: 11
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        3,3',4',5,6,7,8-heptamethoxyflavone: 11

Experts

1.	Amakura, Yoshiaki: 4 articles (04/2016 - 10/2012)
2.	Furukawa, Yoshiko: 4 articles (04/2016 - 10/2012)
3.	Nakajima, Mitsunari: 4 articles (04/2016 - 10/2012)
4.	Okuyama, Satoshi: 4 articles (04/2016 - 10/2012)
5.	Yoshimura, Morio: 4 articles (04/2016 - 10/2012)
6.	Miyoshi, Kazuhiro: 3 articles (04/2015 - 10/2012)
7.	Ho, Chi-Tang: 2 articles (03/2019 - 03/2009)
8.	Sawamoto, Atsushi: 2 articles (04/2016 - 05/2014)
9.	Yoshida, Takashi: 2 articles (04/2015 - 10/2012)
10.	Kaji, Miki: 2 articles (05/2014 - 10/2012)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 05/01/2014 - "The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. " 05/01/2014 - "3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model."
2.	Ischemia 04/23/2016 - "We previously reported that the citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a transient global ischemia mouse model. " 10/24/2012 - "In the present study using a transient global ischemia mouse model, we showed that (1) a citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) induced the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) in the hippocampus after ischemia; (2) HMF increased the expression of brain-derived neurotrophic factor (BDNF), a representative neurotrophic factor in the central nervous system, in the hippocampal dentate gyrus, and most BDNF-positive cells were also stained with anti-glial fibrillary acidic protein (one of the major intermediate filament proteins of mature astrocytes) and (3) HMF increased doublecortin positive neuronal precursor cells in the dentate gyrus subventricular zone or subgranular zone. "
3.	Inflammation (Inflammations) 04/15/2015 - "In the present study, we investigated the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). " 04/15/2015 - "3,5,6,7,8,3',4'-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus."
4.	Obesity 03/06/2019 - "However, little is known about the contribution of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) to prevent obesity and regulate lipid metabolism in vivo. " 07/05/2023 - "3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF) could prevent obesity and hyperlipidemia, but its effects on gut microbiota and fecal metabolites remain unclear. "
5.	Hyperlipidemias (Hyperlipidemia) 07/05/2023 - "3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF) could prevent obesity and hyperlipidemia, but its effects on gut microbiota and fecal metabolites remain unclear. " 11/01/2021 - "3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF), a citrus flavonoid, was found to target FKBP38 to suppress the mTOR/P70S6K/SREBPs pathway, reduce lipid level, and potently ameliorate hyperlipidemia and insulin resistance in high fat diet (HFD)-fed mice. "

Related Drugs and Biologics

1.	Flavonoids
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
5.	Nerve Growth Factors (Neurotrophins)
6.	Lipopolysaccharides
7.	Intermediate Filament Proteins
8.	Glial Fibrillary Acidic Protein
9.	nobiletin
10.	tangeretin