HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2,3- bis(2- methoxy- 4- nitro- 5- sulfophenyl)- 5- ((phenylamino)carbonyl)- 2H- tetrazolium hydroxide

structure given in first source

Also Known As:

2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide; XTT tetrazolium

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - Tetrazolium Salts: 107
        2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide: 4

Experts

1.	Figueroa, S: 1 article (03/2003)
2.	González, M P: 1 article (03/2003)
3.	López, E: 1 article (03/2003)
4.	Oset-Gasque, M J: 1 article (03/2003)
5.	Asea, A: 1 article (05/2002)
6.	Calderwood, S K: 1 article (05/2002)
7.	Lechpammer, S: 1 article (05/2002)
8.	Mallick, R: 1 article (05/2002)
9.	Sherman, M Y: 1 article (05/2002)
10.	Zhong, R: 1 article (05/2002)

Related Diseases

1.	Necrosis 03/01/2003 - "(2) Our results indicate that: (1) cadmium is taken up by the neurons in a dose and serum dependent way; (2) cadmium, at concentrations from 1 micro M or 10 micro M (depending on the absence or the presence of serum) up to 100 micro M, decreases the metabolic capacity, which was evaluated by the XTT (tetrazolium salt) test; (3) cadmium induces apoptosis and LDH (lactate dehydrogenase) release in a dose dependent way; (4) in a serum-free medium, the cadmium-induced apoptosis is accompanied by caspase-3 activation; (5) both the caspase-3 activation and the cadmium-induced apoptosis are reversed by N-acethyl-Asp-Glu-Val-Asp-aldehyde (Ac-DEVD-CHO), a selective caspase-3 inhibitor, indicating that the caspase-3 pathway is involved in cadmium-induced apoptosis in cortical neurons; and (6) the cadmium concentrations which produce caspase-3 activation do not modify the intracellular ATP levels; however, higher cadmium concentrations lead to both intracellular ATP depletion and ATP release, but do not increase the caspase-3 activity, indicating that cadmium also produces cellular death by necrosis. "
2.	Ischemia 01/01/1998 - "Using the reduction of XTT-tetrazolium salt as a marker of metabolic sequelae, we assessed the injurious effect of ischemia and the metabolic sequelae in 156 porcine semilunar leaflets. "
3.	Breast Neoplasms (Breast Cancer) 12/01/1998 - "We tested the cytotoxic effects of melatonin on MCF-7 and T47D human breast cancer cell lines by using the SRB (sulforhodamine-B), XTT-tetrazolium, and bromodeoxyuridine (BrdU) assays in 96-well microtiter plates. "
4.	Hyperthermia 05/01/2002 - "Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme."

Related Drugs and Biologics

1.	Salts
2.	Caspase 3 (Caspase-3)
3.	Melatonin
4.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
5.	Cadmium
6.	Bromodeoxyuridine (BrdU)
7.	Aldehydes
8.	Adenosine Triphosphate (ATP)
9.	acetyl-aspartyl-glutamyl-valyl-aspartal
10.	aspartylglutamate