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withangulatin A

a withanolide from Physalis angulata; promotes type II DNA topoisomerase-mediated DNA damage

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnenes: 1
        withangulatin A: 9

Experts

1.	Chen, Chen: 3 articles (10/2021 - 01/2021)
2.	Kong, Lingyi: 2 articles (10/2021 - 10/2020)
3.	Luo, Jianguang: 2 articles (10/2021 - 10/2020)
4.	Kong, Ling-Yi: 2 articles (01/2021 - 01/2021)
5.	Li, Ying: 2 articles (01/2021 - 01/2021)
6.	Liu, Xiao-Qin: 2 articles (01/2021 - 01/2021)
7.	Luo, Jian-Guang: 2 articles (01/2021 - 01/2021)
8.	Zhou, Wu-Xi: 2 articles (01/2021 - 01/2021)
9.	Liu, Jianwen: 2 articles (09/2011 - 02/2010)
10.	Sun, Lijuan: 2 articles (09/2011 - 02/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Novel withangulatin A (WA) derivatives were synthesized and evaluated for antiproliferative activity against four human cancer cell lines (U2OS, MDA-MB-231, HepG2, and A549). " 10/08/2020 - "Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment." 02/15/2010 - "Withangulatin A (WA), an active component isolated from Physalis angulata L., has been reported to possess anti-tumor and trypanocidal activities in model systems via multiple biochemical mechanisms. " 02/01/2008 - "Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. "
2.	Brain Neoplasms (Brain Tumor) 07/01/1993 - "Induction of vimentin modification and vimentin-HSP72 association by withangulatin A in 9L rat brain tumor cells." 10/01/1991 - "Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells."
3.	Triple Negative Breast Neoplasms 01/15/2021 - "To develop novel GLS1 inhibitors as effective therapeutic agents for triple-negative breast cancer (TNBC), 25 derivatives were synthesized from the natural inhibitor withangulatin A (IC50 = 18.2 μM). " 01/15/2021 - "Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer."
4.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2008 - "Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. "
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 09/01/2011 - "Amelioration of systemic lupus erythematosus by Withangulatin A in MRL/lpr mice."

Related Drugs and Biologics

1.	Topoisomerase II Inhibitors
2.	Peroxiredoxin VI
3.	Vimentin
4.	Proteins (Proteins, Gene)
5.	Glutaminase
6.	withangulatin I