leinamycin (DC 107)

a thiazole containing macrolide characterized by an unusual 1,3-dioxo-1,2-dithiolane moiety that is spiro fused to an 18 member macrolactam ring; isolated from Streptomyces; MF C22-H26-N2-O6-S3; possible DNA alkylator; the leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus S-140 consists of two polyketide synthases genes

Also Known As:

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sun, Daekyu: 3 articles (01/2013 - 08/2004)
2.	Gates, Kent S: 2 articles (01/2013 - 05/2008)
3.	Keerthi, Kripa: 1 article (01/2013)
4.	Rajapakse, Anuruddha: 1 article (01/2013)
5.	Gates, Kent: 1 article (01/2010)
6.	Viswesh, Velliyur: 1 article (01/2010)
7.	Sivaramakrishnan, Santhosh: 1 article (05/2008)
8.	Bacskay, Ildikó: 1 article (09/2006)
9.	Fehér, Palma: 1 article (09/2006)
10.	Fenyvesi, Ferenc: 1 article (09/2006)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 08/01/2004 - "Here, we evaluated the effects of leinamycin in the human pancreatic carcinoma cell line MiaPaCa. " 08/01/2004 - "Cellular response and molecular mechanism of antitumor activity by leinamycin in MiaPaCa human pancreatic cancer cells." 01/01/2010 - "In the present study, we have determined the endogenous amount of AP sites and DNA strand breaks in genomic DNA and the amount of oxidative stress in a human pancreatic carcinoma cell line, MiaPaCa, treated with leinamycin by utilizing the aldehyde-reactive probe assay, the comet assay, and fluorescent probes, respectively. "
2.	Neoplasms (Cancer) 01/01/2013 - "Leinamycin (1) is a Streptomyces-derived natural product that displays nanomolar IC(50) values against human cancer cell lines. " 01/01/2010 - "Leinamycin is a structurally novel Streptomyces-derived natural product that displays very potent activity against various human cancer cell lines (IC(50) values in the low nanomolar range). " 09/07/2006 - "All of these analogues of leinamycin showed cytotoxic activity against HeLa3 tumor cells. " 10/01/1995 - "The percentage of tumor area 6 weeks after therapy was 30.8% of the metropeutic size in the Group DC+CT, 46.8% in the Group DC, 107% in the Group CT and 267% in the control (Group DC+CT vs the other groups: p < 0.05). " 01/01/2010 - "Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells."

Related Drugs and Biologics

1.	Fluorescent Dyes (Fluorescent Probes)
2.	DNA (Deoxyribonucleic Acid)
3.	O-(biotinylcarbazoylmethyl)hydroxylamine
4.	Anti-Bacterial Agents (Antibiotics)
5.	S-deoxyleinamycin
6.	KF 22678

Related Therapies and Procedures

1.	Therapeutics