sepimostate mesilate

used in therapy of pancreatitis; structure given in first source

Also Known As:

6-amidino-2-naphthyl-(4-(4,5-dihydro-1H-imidazol-2-yl)amino)benzoate dimethanesulfonate; FUT 187; FUT-187; Benzoic acid, 4-((4,5-dihydro-1H-imidazol-2-yl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate

Networked: 10 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - sepimostate mesilate: 10

Experts

1.	Kanno, S: 1 article (02/2001)
2.	Koshiyama, Y: 1 article (02/2001)
3.	Kurumi, M: 1 article (02/2001)
4.	Nishioka, M: 1 article (02/2001)
5.	Ohtani, H: 1 article (02/2001)
6.	Suzuki, R: 1 article (02/2001)
7.	Tsuruda, A: 1 article (02/2001)

Related Diseases

1.	Sepsis (Septicemia) 03/01/1996 - "These results indicate that the exocrine pancreas is injured during sepsis, and that some unknown protease activities, which are present during sepsis and are susceptible to the inhibition of FUT-187, seem to play an important role in the pathogenesis of the pancreatic injuries induced by fecal peritonitis. " 03/01/1996 - "To evaluate the effects of sepsis on the exocrine pancreas, we studied (1) serum amylase levels, pancreatic water and trypsin content; (2) pancreatic histological changes; (3) pancreatic subcellular distribution of lysosomal enzyme in the acinar cells; and (4) protective effects of a new synthetic protease inhibitor, FUT-187 against the pancreatic injuries in sepsis of rats induced by cecal ligation and puncture. "
2.	Wounds and Injuries (Trauma) 03/01/1996 - "FUT-187 was found to significantly prevent these pancreatic injuries induced by fecal peritonitis. " 03/01/1996 - "These results indicate that the exocrine pancreas is injured during sepsis, and that some unknown protease activities, which are present during sepsis and are susceptible to the inhibition of FUT-187, seem to play an important role in the pathogenesis of the pancreatic injuries induced by fecal peritonitis. " 03/01/1996 - "To evaluate the effects of sepsis on the exocrine pancreas, we studied (1) serum amylase levels, pancreatic water and trypsin content; (2) pancreatic histological changes; (3) pancreatic subcellular distribution of lysosomal enzyme in the acinar cells; and (4) protective effects of a new synthetic protease inhibitor, FUT-187 against the pancreatic injuries in sepsis of rats induced by cecal ligation and puncture. "
3.	Peptic Esophagitis (Reflux Esophagitis) 03/01/1995 - "FUT-187 was orally administered to 38 patients with postgastrectomy reflux esophagitis for 4 weeks. " 05/01/1994 - "Based on these results, it may be concluded that FUT-187 can be a drug with clinical utility that benefits postgastrectomy reflux esophagitis at the dose level of 300 mg/day or less." 05/01/1994 - "An early phase II clinical study with the proteolysis inhibitor FUT-187 was carried out on patients with reflux esophagitis. " 03/01/1995 - "[Clinical effects of FUT-187 in reflux esophagitis after gastrectomy]." 05/01/1995 - "Based on the results of this study, it may be concluded that FUT-187 is an effective drug with a wide margin of safety for postgastrectomy reflux esophagitis and gastric remnant inflammation."
4.	Inflammation (Inflammations) 05/01/1995 - "Based on the results of this study, it may be concluded that FUT-187 is an effective drug with a wide margin of safety for postgastrectomy reflux esophagitis and gastric remnant inflammation." 12/01/1996 - "[Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant]." 05/01/1995 - "The efficacy and safety of the proteolytic enzyme inhibitor FUT-187 were evaluated in postgastrectomy reflux esophagitis and gastric remnant inflammation. "
5.	Venous Thrombosis (Deep-Vein Thrombosis) 02/01/2001 - "In the present study, the oral administration of FUT-187 inhibited stasis-induced venous thrombosis in rats. " 02/01/2001 - "Consequently, we consider that the inhibitory effect of FUT-187 on venous thrombosis model is caused by fibrinolysis, which is attributable to the 20-kDa fragment, rather than by inhibition of thrombus formation."

Related Drugs and Biologics

1.	Trypsin
2.	Protease Inhibitors (Protease Inhibitor)
3.	Enzymes
4.	Amylases
5.	Mesylates (Mesylate)
6.	Therapeutic Uses
7.	Peptide Hydrolases (Proteases)
8.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
9.	Phospholipases (Phospholipase)
10.	Fibrinolysin

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Oral Administration
4.	Gastrectomy