grifolin

10/18/2016 - "In this study, we observed that grifolin inhibited tumor cells adhesion and migration. "
11/30/2011 - "Grifolin, a secondary metabolite isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, has been shown to induce G1 phase cell-cycle arrest in tumor cells in previous studies of our group. "
01/01/2011 - "Grifolin, a secondary metabolite isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, has been shown to inhibit the growth of some cancer cell lines in vitro by induction of apoptosis in previous studies of our group. "
01/03/2022 - "In addition, grifolin exhibited remarkable anti-cancer effects on different human cancer cells. "
01/01/2018 - "In addition, grifolin might be a promising lead compound in the intervention of high-CIMP tumor types. "

06/01/2017 - "The aim of the present study was to examine the effect of grifolin treatment on the human ovarian cancer cell line, A2780. "
08/01/2016 - "The present study indicated that grifolin could induce autophagic cell death in human ovarian cancer by inhibiting the Akt/mTOR/S6K pathway. "
06/01/2017 - "These results demonstrate the therapeutic potential of grifolin as a treatment for ovarian cancer."
06/01/2017 - "Grifolin induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways."
08/01/2016 - "Flow cytometry, electron microscopy, immunofluorescence and GFP-LC3 puncta formation assay proved that grifolin induces autophagic cell death in human ovarian cancer. "

07/01/2007 - "In this study, we investigated the apoptosis-inducing effects and the mechanisms of grifolin on human osteosarcoma cells. "
07/01/2007 - "Our results demonstrated that grifolin induced concentration- and time-dependent suppression of proliferation and induction of apoptosis in U2OS and MG63 osteosarcoma cell lines. "
07/01/2007 - "Grifolin induces apoptosis via inhibition of PI3K/AKT signalling pathway in human osteosarcoma cells."
07/01/2007 - "Taken together, our results suggested that grifolin is able to suppress the phosphorylation of Akt and its substrates FOXO transcription factor and GSK3 in osteosarcoma cells causing the suppression of proliferation and induction of mitochondria- and caspase-dependent apoptosis."
07/01/2007 - "On the other hand, grifolin treatment down-regulated the expression of the inhibitor of apoptosis protein(IAP) in both osteosarcoma cells. "

03/28/2017 - "The data obtained in this study revealed that grifolin is capable of inhibiting the growth and invasion of gastric cancer cells by inducing apoptosis and suppressing the ERK1/2 pathway. "
03/28/2017 - "Our results support the potent utility of grifolin as an anti-tumor lead compound against gastric cancer cells."

11/30/2011 - "The similar effects induced by grifolin and mechanism beneath were identified in another nasopharyngeal carcinoma cell HONE1. "
11/30/2011 - "Here, we found that grifolin induced dephosphorylation of DAPK1 (Ser308) to activate DAPK1 and subsequent phosphorylation of its potential downstream effector p21 (Thr145) in nasopharyngeal carcinoma cell CNE1. "
11/30/2011 - "DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product."
12/18/2007 - "We found that the effect of grifolin on the human nasopharyngeal carcinoma cell line CNE1 occurs primarily via the ERK1/2 pathway. "
01/01/2018 - "DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma."