1,5-dihydro-FAD

chromophore component of E coli DNA photolyase

Also Known As:

FADH2

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Flavin-Adenine Dinucleotide: 1493
        1,5-dihydro-FAD: 8
    - Pteridines: 147
      - Flavins: 50
        Riboflavin: 2218
        Flavin-Adenine Dinucleotide: 1493
        1,5-dihydro-FAD: 8
  - 3-Ring Heterocyclic Compounds
    - Flavins: 50
      - Riboflavin: 2218
        Flavin-Adenine Dinucleotide: 1493
        1,5-dihydro-FAD: 8
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Flavins: 50
    - Riboflavin: 2218
      - Flavin-Adenine Dinucleotide: 1493
        1,5-dihydro-FAD: 8
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Adenine Nucleotides: 1066
      - Flavin-Adenine Dinucleotide: 1493
        1,5-dihydro-FAD: 8
  - Purine Nucleotides: 140
    - Adenine Nucleotides: 1066
      - Flavin-Adenine Dinucleotide: 1493
        1,5-dihydro-FAD: 8
Biological Factors: 2472
- Biological Pigments: 1
  - Flavins: 50
    - Riboflavin: 2218
      - Flavin-Adenine Dinucleotide: 1493
        1,5-dihydro-FAD: 8

Experts

1.	Arthiga, K: 1 article (09/2022)
2.	Jain, Vikas: 1 article (09/2022)
3.	Patil, Amit B: 1 article (09/2022)
4.	Preethi, S: 1 article (09/2022)
5.	Spandana, Asha: 1 article (09/2022)
6.	Chen, Zhaoli: 1 article (12/2021)
7.	Li, Mingzhe: 1 article (12/2021)
8.	Liu, Chang: 1 article (12/2021)
9.	Liu, Weili: 1 article (12/2021)
10.	Pu, Lingling: 1 article (12/2021)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2021 - "Flavin adenine dinucleotide (FADH2; 10 µM) was effective in recycling GSSG in vivo and promoted alveologenesis, but did not impact AFC nor attenuate fibrosis following high [Formula: see text] exposure. "
2.	Neoplasms (Cancer) 01/01/2023 - "The oxidation of NADH2 and FADH2 are fundamental since NAD and FAD are the key components of the TCA-cycle that is critical to entertain biosynthesis in cancer cells. " 08/09/2021 - "While maintaining its capacity to inhibit mitochondrial oxidative phosphorylation, metformin lost its cytotoxic and antiproliferative activity in SHMT2-null cancer cells unable to produce energy-rich NADH or FADH2 molecules from tricarboxylic acid cycle (TCA) metabolites. " 09/01/2022 - "The mechanism of NQO1 by the reduction of FAD by NADPH to form FADH2 is by two ways to inhibit cancer cell development such as suppression of carcinogenic metabolic activation and prevention of carcinogen formation. "
3.	Hypoxia (Hypoxemia) 12/01/2021 - "Under hypoxia, mitochondrial NADH and FADH2 cannot be oxidized by the mitochondrial electron transport chain, which leads to the accumulation of reducing equivalents and subsequent reduction stress. " 01/01/2023 - "Also, the fungus was starved of oxygen throughout fermentation, and the NADH and FADH2 are unable to transfer hydrogen under hypoxia, resulting in the inability of NAD and FAD to regenerate and inhibit the tricarboxylic acid cycle of cells. " 07/01/2007 - "In combination with the hypoxia-induced expression of LDHA (lactate dehydrogenase A), which converts pyruvate into lactate, PDK1 reduces the delivery of acetyl-CoA to the tricarboxylic acid cycle, thus reducing the levels of NADH and FADH2 delivered to the electron-transport chain. "
4.	Lung Injury 01/01/2021 - "In conclusion, the data indicate that FADH2 may be pivotal for normal lung development, and show that ENaC is a key factor in promoting alveologenesis, sustaining AFC, and attenuating fibrotic lung injury caused by prolonged oxygen therapy in WT mice."
5.	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 01/01/2021 - "Multiple acyl-coenzyme A dehydrogenase deficiency (MADD), or glutaric aciduria type II (GAII), is a group of clinically heterogeneous disorders caused by mutations in electron transfer flavoprotein (ETF) and ETF-ubiquinone oxidoreductase (ETFQO) - the two enzymes responsible for the re-oxidation of enzyme-bound flavin adenine dinucleotide (FADH2) via electron transfer to the respiratory chain at the level of coenzyme Q10. "

Related Drugs and Biologics

1.	Flavin-Adenine Dinucleotide (FAD)
2.	Glutathione Disulfide (GSSG)
3.	NAD (NADH)
4.	Oxygen (Dioxygen)
5.	Electron-Transferring Flavoproteins (Electron Transfer Flavoprotein)
6.	Lactic Acid (Lactate)
7.	Pyruvic Acid (Pyruvate)
8.	Ubiquinone
9.	Oxidoreductases (Dehydrogenase)
10.	NADP (NADPH)

Related Therapies and Procedures

1.	Therapeutics