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2- (2- (5- carboxy)oxazole)- 5- hydroxy- 6- aminobenzofuran- N,N,O- triacetic acid

structure given in first source

Also Known As:

FURAPTRA; mag-fura-2; magfura-2

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Fura-2: 457
        2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-N,N,O-triacetic acid: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - Fura-2: 457
        2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-N,N,O-triacetic acid: 7

Experts

1.	Pei, Lei: 1 article (06/2011)
2.	Shi, Jing: 1 article (06/2011)
3.	Sun, Ning: 1 article (06/2011)
4.	Wang, Jing: 1 article (06/2011)
5.	Zhang, Jing: 1 article (06/2011)
6.	Zhao, Fengbo: 1 article (06/2011)
7.	Zhao, Yin: 1 article (06/2011)
8.	Abukhdeir, Abde M: 1 article (02/2003)
9.	Bryant, Fred B: 1 article (02/2003)
10.	Layden, Brian T: 1 article (02/2003)

Related Diseases

1.	Ischemia 10/01/1994 - "Use of quantitative digital imaging microscopy, and mag-fura-2, on single-cultured canine cerebral vascular smooth muscle, human endothelial, and rat astrocyte cells reveals that alcohol induces rapid concentration-dependent depletion of [Mg2+]i. These cellular deficits in [Mg2+]i seem to precipitate cellular and subcellular disturbances in cytoplasmic and mitochondrial bioenergetic pathways leading to Ca2+ overload and ischemia. " 06/10/2011 - "This study aimed to explore whether magnesium was transported via a TRPM7 channel into the intracellular space of rat hippocampal neurons after 1 h of oxygen-glucose deprivation (OGD) and acute chemical ischemia (CI) by using methods of the Mg(2+) fluorescent probe Mag-Fura-2 to detect intracellular magnesium concentration ([Mg(2+)](i)) and flame atomic absorption spectrometry to measure extracellular magnesium concentration ([Mg(2+)](o)). "
2.	Neuroblastoma 02/01/2003 - "In human neuroblastoma cells, intracellular free Mg2+ was determined by fluorescence spectroscopy with the fluorophore furaptra. " 06/01/1999 - "By fluorescence spectroscopy with furaptra-loaded cells, the free intracellular Mg2+ concentration within the intact neuroblastoma cells was found to increase from 0. " 09/01/2000 - "We used fluorescence spectroscopy and a Mg2+ indicator, furaptra, to investigate this competition in human neuroblastoma SH-SY5Y cells. "
3.	Hypertension (High Blood Pressure) 01/01/1998 - "To evaluate the relative effect of hypertension and plasma triglycerides on intralymphocyte magnesium we measured ionized intralymphocyte magnesium (Mg(i)) concentration by means of a fluorimetric method based on the dye Furaptra in 4 groups of subjects: 18 normotensive normotriglyceridemic controls (NTNC), 9 hypertriglyceridemic normotensive patients (HTN), 8 hypertriglyceridemic essential hypertensive patients (HTEH), 17 normotriglyceridemic essential hypertensive patients (NTEH). "
4.	Hypoxia (Hypoxemia) 03/01/1994 - "A small increase in mag-fura-2 fluorescence was noted, probably due to binding of Ca2+ to the fluoroprobe when [Ca2]i exceeded 1 mM. Elimination of Ca2+ from the extracellular buffer increased the resting estimate of intracellular [Mg2+] to 1.6 + .1 mM. These results indicate that 1) extracellular Ca2+ can interfere with the fluorescent determination of intracellular magnesium concentration, and 2) intracellular free Mg2+ concentrations do not change in this cell line during chemical anoxia."

Related Drugs and Biologics

1.	Magnesium
2.	Oxygen (Dioxygen)
3.	Glucose (Dextrose)
4.	Fluorescent Dyes (Fluorescent Probes)
5.	Triglycerides (Triacylglycerol)
6.	Indicators and Reagents (Reagents)
7.	Coloring Agents (Dyes)
8.	Buffers