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5-hydroxy-6,8,11,14,17-eicosapentaenoic acid

RN given refers to (E,Z,Z,Z,Z)-isomer; RN for cpd without isomeric designation not available 4/89

Also Known As:

5-HEPE; 5-hydroxyeicosapentaenoic acid

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bartke, Andrzej: 1 article (12/2020)
2.	Bussburg, Valerie: 1 article (12/2020)
3.	Darcy, Justin: 1 article (12/2020)
4.	Dreyfuss, Jonathan M: 1 article (12/2020)
5.	Fang, Yimin: 1 article (12/2020)
6.	Greenwood, Bennett: 1 article (12/2020)
7.	Kiebish, Michael A: 1 article (12/2020)
8.	Leiria, Luiz O: 1 article (12/2020)
9.	Lynes, Matthew D: 1 article (12/2020)
10.	McFadden, Samuel: 1 article (12/2020)

Related Diseases

1.	Insulin Resistance 06/15/2023 - "In vivo, our results demonstrated that 5-HEPE alleviated the HFD-induced obesity and insulin resistance, leading to a significant decrease in subcutaneous fat and epididymal fat index and an increase in brown fat index. " 06/15/2023 - "5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation." 12/01/2020 - "Importantly, 5-HEPE is increased in other models of BAT activation and is negatively correlated with body weight, insulin resistance, and circulating triglyceride concentrations in humans. "
2.	Non-alcoholic Fatty Liver Disease 07/01/2017 - "17,18-EEQ, 5-HEPE and 9-HEPE may be potential approaches to prevent NAFLD in the early stage by inhibiting the inflammatory response in adipose tissue macrophages via JNK signalling."
3.	Obesity 06/15/2023 - "Our results suggest that 5-HEPE intervention may be an effective target for preventing obesity-related metabolic diseases." 06/15/2023 - "In vivo, our results demonstrated that 5-HEPE alleviated the HFD-induced obesity and insulin resistance, leading to a significant decrease in subcutaneous fat and epididymal fat index and an increase in brown fat index. " 06/15/2023 - "5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation."
4.	Metabolic Diseases (Metabolic Disease) 06/15/2023 - "Our results suggest that 5-HEPE intervention may be an effective target for preventing obesity-related metabolic diseases."
5.	Insulinoma 12/09/2011 - "5-HEPE stimulated cAMP accumulation in mouse MIN6 insulinoma cells and human HuTu80 intestinal adenocarcinoma cells. "

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