|1.||Delpire, Eric: 6 articles (03/2010 - 01/2002)|
|2.||Mount, David B: 6 articles (01/2010 - 01/2002)|
|3.||Rouleau, Guy A: 5 articles (07/2014 - 11/2002)|
|4.||Shen, Meng-Ru: 5 articles (11/2011 - 10/2003)|
|5.||Ellory, J Clive: 5 articles (11/2011 - 10/2003)|
|6.||Chou, Cheng-Yang: 4 articles (11/2009 - 10/2003)|
|7.||Kahle, Kristopher T: 3 articles (01/2015 - 05/2014)|
|8.||Dion, Patrick A: 3 articles (07/2014 - 03/2012)|
|9.||Shekarabi, Masoud: 3 articles (01/2013 - 02/2011)|
|10.||Laganière, Janet: 3 articles (01/2013 - 02/2011)|
|1.||Dehydration (Water Stress)
09/15/2014 - "We hypothesized that should 5HMF also inhibit the main cation pathways implicated in the dehydration of RBCs from SCD patients - the deoxygenation-induced cation pathway (Psickle), the Ca(2+)-activated K(+) channel (the Gardos channel) and the K(+)-Cl(-) cotransporter (KCC) - it would have a synergistic effect in protection against sickling, directly through interacting with HbS, and indirectly through maintaining hydration and reducing [HbS]. "
01/01/2005 - "Predictions derived from mathematical models of red cell and reticulocyte homeostasis led to the formulation of an alternative to prevailing gradualist views: a multitrack dehydration model based on interactive influences between the red cell anion exchanger and two K(+) transporters, the Gardos channel (hSK4, hIK1) and the K-Cl cotransporter (KCC), with differential effects dependent on red cell age and variability of KCC expression among reticulocytes. "
03/01/2002 - "This article reviews knowledge of the dehydration mechanism, stressing the marked heterogeneity of dehydration rates in sickle cell populations, and discusses recent contributions to understanding of the function and regulation of P (sickle), Ca 2+ -sensitive K channel, and K:Cl cotransporter, and of therapies targeted at these transporters."
03/01/2002 - "This permeability, usually described as P (sickle), triggers a chain of events in which two constitutive transporters of the red cell membrane become activated-the recently cloned intermediate conductance, Ca 2+ -sensitive K channel, and the electroneutral K:Cl cotransporter-leading to sickle cell dehydration. "
12/01/2000 - "The KCl cotransporter (KCCl) is capable of mediating sickle cell dehydration. "
11/21/2012 - "A reduction in the expression and function of the potassium-chloride cotransporter 2 occurred during chronic pain, which reduces the efficacy of the inhibitory inputs to L2/3 excitatory neurons. "
11/21/2012 - "Enhanced GABAergic activity in the mouse primary somatosensory cortex is insufficient to alleviate chronic pain behavior with reduced expression of neuronal potassium-chloride cotransporter."
10/01/2013 - "In the nucleus raphe magnus (NRM), a critical relay in the brain's descending pain-modulating system, persistent inflammatory pain induced by complete Freund's adjuvant decreased the protein level of K(+)-Cl(-) cotransporter (KCC2) in both total and synaptosomal preparations. "
10/01/2013 - "Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation."
06/01/2013 - "Two members of the CCC family, KCC2 (the major neuron-specific K-Cl cotransporter; KCC isoform 2) and NKCC1 (the Na-K-2Cl cotransporter isoform 1 which is expressed in both neurons and glial cells) have attracted much interest in studies on GABAergic signaling under both normal and pathophysiological conditions, such as epilepsy. "
07/01/2014 - "The KCl-cotransporter KCC2 linked to epilepsy."
01/01/2002 - "Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene."
01/01/2002 - "Targeted deletion of the neuronal-specific K-Cl cotransporter KCC2 generates mice with a profound seizure disorder and confirms the central role of this transporter in modulating neuronal excitability. "
01/01/2015 - "GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy."
|4.||Schizophrenia (Dementia Praecox)
01/01/2015 - "In this study, we performed Western blot analysis to investigate whether the Na-K-Cl and K-Cl cotransporter protein is abnormally expressed in the dorsal lateral prefrontal cortex and the anterior cingulate cortex in patients with schizophrenia versus a control group. "
01/01/2015 - "We found decreased K-Cl cotransporter protein expression in the dorsal lateral prefrontal cortex, but not the anterior cingulate cortex, in subjects with schizophrenia, supporting the hypothesis of region level abnormal GABAergic function in the pathophysiology of schizophrenia. "
01/01/2015 - "Subjects with schizophrenia off antipsychotic medication at the time of death had decreased K-Cl cotransporter protein expression compared to both normal controls and subjects with schizophrenia on antipsychotics. "
11/01/2012 - "To study changes in the expression levels of parvalbumin (PV), glutamate decarboxylase 67 (GAD67) and K+-Cl- cotransporter 2 (KCC2) in the brain tissue of rats with schizophrenia (SZ) induced by dizocilpine (MK-801), and to investigate the mechanism involving gamma-aminobutyric acid (GABA) by which NMDA receptor blocker induces SZ in the perinatal period. "
|5.||Spinal Cord Injuries (Spinal Cord Injury)
03/01/2010 - "Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury."
11/01/2006 - "K-Cl cotransporter KCC2 immunohistochemistry revealed a developmental increase of staining in the area of lumbar motoneurons between P0 and P7 in cord-intact animals; this increase was not observed after spinal cord transection. "
01/01/2014 - "Loss of the inhibitory tone induced by downregulation of the potassium chloride cotransporter 2 (KCC2) in MN has been proposed to importantly contribute to the spastic behavior after spinal cord injury (SCI). "
01/01/2008 - "This study investigated the role of two major intracellular Cl- regulatory proteins, Na+-K+-Cl- cotransporter 1 (NKCC1) and K+-Cl- cotransporter 2 (KCC2), in neuropathic pain following spinal cord injury (SCI). "
|2.||gamma-Aminobutyric Acid (GABA)
|3.||Proteins (Proteins, Gene)
|4.||Dizocilpine Maleate (Dizocilpine)
|6.||Glutamate Decarboxylase (Decarboxylase, Glutamate)
|7.||Messenger RNA (mRNA)
|8.||GABA-A Receptors (GABA(A) Receptor)
|9.||Aminobutyric Acids (Aminobutyric Acid)
|10.||GABA Plasma Membrane Transport Proteins