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potassium-chloride symporters

Also Known As:
K(+), Cl(-)-cotransporter; K-Cl cotransporter; KCC1 cotransporter; KCC1 cotransporter, mouse; KCC1 protein, human; KCC2 cotransporter; KCC2 protein, mouse; KCl cotransporter; SLC12A4 protein, human; Slc12a4 protein, mouse; Slc12a5 protein, mouse; potassium, chloride-cotransporter; solute carrier family 12 (potassium/chloride transporters), member 4 protein, human; solute carrier family 12, member 4 protein, mouse
Networked: 70 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Delpire, Eric: 6 articles (03/2010 - 01/2002)
2. Mount, David B: 6 articles (01/2010 - 01/2002)
3. Rouleau, Guy A: 5 articles (07/2014 - 11/2002)
4. Shen, Meng-Ru: 5 articles (11/2011 - 10/2003)
5. Ellory, J Clive: 5 articles (11/2011 - 10/2003)
6. Chou, Cheng-Yang: 4 articles (11/2009 - 10/2003)
7. Kahle, Kristopher T: 3 articles (01/2015 - 05/2014)
8. Dion, Patrick A: 3 articles (07/2014 - 03/2012)
9. Shekarabi, Masoud: 3 articles (01/2013 - 02/2011)
10. Laganière, Janet: 3 articles (01/2013 - 02/2011)

Related Diseases

1. Dehydration (Water Stress)
09/15/2014 - "We hypothesized that should 5HMF also inhibit the main cation pathways implicated in the dehydration of RBCs from SCD patients - the deoxygenation-induced cation pathway (Psickle), the Ca(2+)-activated K(+) channel (the Gardos channel) and the K(+)-Cl(-) cotransporter (KCC) - it would have a synergistic effect in protection against sickling, directly through interacting with HbS, and indirectly through maintaining hydration and reducing [HbS]. "
01/01/2005 - "Predictions derived from mathematical models of red cell and reticulocyte homeostasis led to the formulation of an alternative to prevailing gradualist views: a multitrack dehydration model based on interactive influences between the red cell anion exchanger and two K(+) transporters, the Gardos channel (hSK4, hIK1) and the K-Cl cotransporter (KCC), with differential effects dependent on red cell age and variability of KCC expression among reticulocytes. "
03/01/2002 - "This article reviews knowledge of the dehydration mechanism, stressing the marked heterogeneity of dehydration rates in sickle cell populations, and discusses recent contributions to understanding of the function and regulation of P (sickle), Ca 2+ -sensitive K channel, and K:Cl cotransporter, and of therapies targeted at these transporters."
03/01/2002 - "This permeability, usually described as P (sickle), triggers a chain of events in which two constitutive transporters of the red cell membrane become activated-the recently cloned intermediate conductance, Ca 2+ -sensitive K channel, and the electroneutral K:Cl cotransporter-leading to sickle cell dehydration. "
12/01/2000 - "The KCl cotransporter (KCCl) is capable of mediating sickle cell dehydration. "
2. Pain (Aches)
3. Epilepsy (Aura)
4. Schizophrenia (Dementia Praecox)
5. Spinal Cord Injuries (Spinal Cord Injury)

Related Drugs and Biologics

1. Sodium-Potassium-Chloride Symporters
2. gamma-Aminobutyric Acid (GABA)
3. Proteins (Proteins, Gene)
4. Dizocilpine Maleate (Dizocilpine)
5. N-Methylaspartate (NMDA)
6. Glutamate Decarboxylase (Decarboxylase, Glutamate)
7. Messenger RNA (mRNA)
8. GABA-A Receptors (GABA(A) Receptor)
9. Aminobutyric Acids (Aminobutyric Acid)
10. GABA Plasma Membrane Transport Proteins

Related Therapies and Procedures

1. Ovariectomy (Oophorectomy)
2. Analgesia