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abanoquil

Also Known As:

4-amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinol-2-yl)quinoline methanesulfonate; UK 52046; UK 52046-27; UK-52,046; UK-52046

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        abanoquil: 7
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        abanoquil: 7

Experts

1.	Giraldi,: 1 article (03/2000)
2.	Giraldi, A: 1 article (03/2000)
3.	Wagner,: 1 article (03/2000)
4.	Wagner, G: 1 article (03/2000)
5.	Wyllie,: 1 article (03/2000)
6.	Wyllie, M: 1 article (03/2000)

Related Diseases

1.	Ventricular Premature Complexes (Premature Ventricular Contraction) 12/01/1988 - "5. In a study of the early (1a/1b) arrhythmias of acute myocardial ischaemia, the total number of ventricular ectopic beats occurring within 30 min of CAL was not reduced by 4 micrograms kg-1 UK-52046 but fell (P less than 0.01 compared with placebo) after 8 micrograms kg-1 [median values with ranges for placebo, 4 micrograms kg-1 and 8 micrograms kg-1 respectively 190 (4-674), 246 (9-1204) and 12 (1-154)]. " 12/01/1988 - "3. UK-52046, 3.7 +/- 1.4 micrograms kg-1, prevented adrenaline-induced arrhythmias 3-4 days after CAL in 6/6 conscious dogs; atenolol in doses of up to 100 micrograms kg-1 produced an 84.4 +/- 7.4% reduction in the number of ventricular ectopic beats. "
2.	Erectile Dysfunction 03/01/2000 - "Hence, abanoquil might be useful as a facilitator of erection in the pharmacological treatment of erectile dysfunction." 03/01/2000 - "Hence, abanoquil might be useful as a facilitator of erection in the pharmacological treatment of erectile dysfunction. "
3.	Ventricular Fibrillation 06/07/1995 - "Abanoquil at concentrations of 0.03, 0.1 and 0.3 microM tended to reduce the incidence of reperfusion-induced ventricular fibrillation (VF) in a dose-dependent manner from 75% in controls to 58, 33 and 25%, but this effects did not achieve statistical significance. "
4.	Tachycardia (Tachyarrhythmias) 11/01/1991 - "5. In conclusion, significant alpha 1-adrenoceptor antagonism without marked reflex tachycardia or profound postural hypotension suggest that abanoquil has a different haemodynamic profile from that of 'classical' peripheral alpha 1-adrenoceptor antagonists."
5.	Orthostatic Hypotension (Postural Hypotension) 11/01/1991 - "5. In conclusion, significant alpha 1-adrenoceptor antagonism without marked reflex tachycardia or profound postural hypotension suggest that abanoquil has a different haemodynamic profile from that of 'classical' peripheral alpha 1-adrenoceptor antagonists."

Related Drugs and Biologics

1.	Propranolol (Inderal)
2.	Prazosin (Minipress)
3.	Epinephrine (Adrenaline)
4.	Atenolol (Tenormin)