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cyprodime

RN & structure given in first source; RN given refers to parent cpd

Also Known As:

N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one; cyprodime hydrobromide

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Baamonde, Ana: 2 articles (10/2008 - 05/2005)
2.	Hidalgo, Agustín: 2 articles (10/2008 - 05/2005)
3.	Meana, Alvaro: 2 articles (10/2008 - 05/2005)
4.	Menéndez, Luis: 2 articles (10/2008 - 05/2005)
5.	Fournié-Zaluski, Marie-Claude: 1 article (10/2008)
6.	Poras, Hervé: 1 article (10/2008)
7.	Roques, Bernard P: 1 article (10/2008)
8.	Lastra, Ana: 1 article (05/2005)

Related Diseases

1.	Hyperalgesia 10/31/2008 - "Oral administration of PL37 (25 mg/kg) completely supressed osteosarcoma-induced thermal hyperalgesia through the activation of micro-opioid receptors, since the administration of cyprodime (1 mg/kg) inhibited its antihyperalgesic effect. " 05/01/2005 - "Furthermore, only cyprodime (1 mg/kg) but not naltrindole (0.1 mg/kg) or nor-binaltorphimine (10 mg/kg) blocked these effects, showing the involvement of gamma-opioid receptors in the peripheral analgesia induced by loperamide on thermal and mechanical hyperalgesia. "
2.	Osteosarcoma (Osteogenic Sarcoma) 10/31/2008 - "Oral administration of PL37 (25 mg/kg) completely supressed osteosarcoma-induced thermal hyperalgesia through the activation of micro-opioid receptors, since the administration of cyprodime (1 mg/kg) inhibited its antihyperalgesic effect. "
3.	Neuralgia (Stump Neuralgia) 02/19/1999 - "Those effects of endomorphins were antagonized in acute (30 microg), inflammatory (30 microg) and neuropathic pain models (60 microg) by cyprodime, a selective mu-opioid receptor antagonist. "
4.	Contracture 03/01/1996 - "A withdrawal contracture to the selective mu antagonist, cyprodime, after repeated exposures to a selective mu agonist, dermorphin, was restored by nor-binaltorphimine (BNI), a selective kappa antagonist. "

Related Drugs and Biologics

1.	Opioid Receptors (Opioid Receptor)
2.	norbinaltorphimine
3.	mu Opioid Receptors (mu Opioid Receptor)
4.	Loperamide (Imodium)
5.	naltrindole
6.	dermorphin

Related Therapies and Procedures

1.	Analgesia
2.	Oral Administration