pseudolaric acid B

from Pseudolarix kaempferi Gordon; structure given in first source

Also Known As:

pseudolarix acid B; 1H-4,9a-Ethanocyclohepta(c)pyran-7-carboxylic acid, 4a-(acetyloxy)-3-(4-carboxy-1,3-pentadienyl)-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-, 7-methyl ester, (3R-(3alpha(1E,3E),4alpha,4aalpha,9aalpha))-

Networked: 67 relevant articles (3 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - pseudolaric acid B: 67

Experts

1.	Onodera, Satoshi: 10 articles (10/2017 - 12/2004)
2.	Ikejima, Takashi: 9 articles (10/2017 - 12/2004)
3.	Tashiro, Shin-ichi: 6 articles (01/2013 - 12/2004)
4.	Yu, Jinghua: 4 articles (12/2020 - 07/2008)
5.	Tashiro, Shin-Ichi: 4 articles (10/2017 - 01/2005)
6.	Liu, Chunyu: 3 articles (12/2020 - 11/2015)
7.	Chen, Hong: 3 articles (06/2018 - 04/2012)
8.	Li, Tan: 3 articles (06/2018 - 04/2012)
9.	Wang, Wei: 3 articles (06/2018 - 08/2012)
10.	Qi, Min: 3 articles (07/2016 - 05/2012)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF-κB signalling pathway." 01/01/2023 - "This study aimed to determine the mechanisms of antifungal and anti-inflammation effects of pseudolaric acid B (PAB) on Aspergillus fumigatus (A. " 01/01/2023 - "Pseudolaric Acid B Ameliorates Fungal Keratitis Progression by Suppressing Inflammation and Reducing Fungal Load." 06/01/2018 - "Pseudolaric acid B attenuates atherosclerosis progression and inflammation by suppressing PPARγ-mediated NF-κB activation." 11/01/2017 - "Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation."
2.	Skin Diseases (Skin Disease) 11/01/2017 - "Pseudolaric acid B (PB), isolated from the extract of the root bark of Pseudolarix kaempferi Gordon, has been used as a traditional remedy for the treatment of skin diseases. " 04/11/2012 - "Pseudolaric acid B (PAB) is a novel diterpenoid, isolated from Pseudolarix kaempferi Gorden, which roots are widely used to treat inflammatory and microbial skin diseases for centuries, but the underlying mechanism remains elusive. " 01/01/2022 - "Pseudolaric acid B (PAB) has long been used to treat fungal-infected dermatosis, and exerted anti-tumor, -fertility, -angiogenesis, -tubulin and antiparasitic activity. "
3.	Keratitis 01/01/2023 - "Pseudolaric Acid B Ameliorates Fungal Keratitis Progression by Suppressing Inflammation and Reducing Fungal Load."
4.	Neoplasms (Cancer) 09/01/2013 - "Numerous studies have demonstrated that pseudolaric acid B (PAB) promotes apoptosis in several cancer cell lines. " 01/01/2023 - "Pseudolaric acid B (PAB), a natural product isolated from the root bark of Pseudolarix kaempferi, has been reported to exert inhibitory effects in various cancers. " 09/01/2019 - "Pseudolaric acid B (PAB) has been shown to inhibit the growth of various tumor cells, but the molecular details of its function are still unknown. " 08/11/2017 - "Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells." 01/01/2017 - "Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi and has been reported to have cytotoxicity against tumor cells. "
5.	Melanoma (Melanoma, Malignant) 04/01/2009 - "The aim of this study was to investigate the mechanism of pseudolaric acid B (PLAB)-induced cell cycle arrest in human melanoma SK-28 cells. " 01/01/2005 - "In our study, pseudolaric acid B inhibited growth of human melanoma cells, A375-S2 in a time- and dose-dependent manner. " 01/01/2005 - "Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells." 01/01/2005 - "[Pseudolaric acid B induces human melanoma A375-S2 cell apoptosis in vitro]." 01/01/1991 - " Recently, pseudolaric acid B was established as a general cytotoxic agent against P-388 lymphocytic leukemia, KB carcinoma of the nasopharynx, HT-1080 fibrosarcoma, H00 578T breast cancer, human melanoma, human lung cancer, and human colon cancer cell lines. "

Related Drugs and Biologics

1.	Diterpenes
2.	Acids
3.	Terpenes (Terpenoids)
4.	Anticarcinogenic Agents
5.	Transcription Factors (Transcription Factor)
6.	Iron
7.	Cysteine (L-Cysteine)
8.	triptolide
9.	Caspases
10.	Proteasome Endopeptidase Complex (Proteasome)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Drug Therapy (Chemotherapy)