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parathyroid hormone (7-34)
Also Known As:
PTH (7-34); bPTH (7-34); bovine parathyroid hormone (7-34)
Networked:
8
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Parathyroid Hormone: 11951
parathyroid hormone (7-34): 8
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Peptide Hormones: 1347
Parathyroid Hormone: 11951
parathyroid hormone (7-34): 8
Peptide Fragments: 373
parathyroid hormone (7-34): 8
Related Diseases
1.
Neoplasms (Cancer)
08/01/1996 - "
Based on these and related studies, the antagonist [Nle8,18,D-Trp12,Tyr34]bPTH(7-34)NH2 has displayed sufficient potency to obtain approval from the appropriate institutional and regulatory agencies for clinical trials in hypercalcemic states of parathyroid and tumor origin.
"
01/01/1988 - "
The similarity in biological profiles despite structural differences between hHCF and PTH is emphasized by the inhibitory action of [Tyr-34]bPTH-(7-34)NH2 against the tumor peptide even in the absence of much of the homologous region in the PTH antagonist.
"
2.
Hypercalcemia (Milk Alkali Syndrome)
05/01/1994 - "
In the present studies, the PTH antagonists [Tyr34]bovine (b) PTH-(7-34)NH2, [D-Trp12,Tyr34]-bPTH-(7-34)NH2, or PTHrP-(7-34)NH2, were administered to hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung in 60- to 500-fold molar excess of a dose of PTHrP-(1-34) known to produce hypercalcemia.
"
3.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
05/01/1994 - "
In the present studies, the PTH antagonists [Tyr34]bovine (b) PTH-(7-34)NH2, [D-Trp12,Tyr34]-bPTH-(7-34)NH2, or PTHrP-(7-34)NH2, were administered to hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung in 60- to 500-fold molar excess of a dose of PTHrP-(1-34) known to produce hypercalcemia.
"
4.
Bone Resorption
09/01/1984 - "
The PTH antagonists [8,18norleucine, 34tyrosine]bovine PTH (3-34) amide and [34tyrosine]bovine PTH (7-34) completely inhibited PTH-stimulated bone resorption.
"
02/01/1987 - "
Neither [8Nle,18Nle,34Tyr]bovine (b) PTH-(3-34) amide nor [34Tyr]bPTH-(7-34)amide inhibited bone resorption or limb bone cAMP accumulation induced by either processed conditioned medium or equivalent concentrations of bPTH-(1-34).
"
5.
Wounds and Injuries (Trauma)
05/01/1999 - "
Topical application of parathyroid hormone related protein (1-36) or parathyroid hormone (7-34) did not result in significant changes in the healing rate and morphology of the wounds.
"
05/01/1999 - "
To define better the role of parathyroid hormone-related protein in the skin, we investigated the spatial and temporal expression of parathyroid hormone-related protein and mRNA by immunohistochemistry and in situ hybridization during the healing of skin wounds, and the effects of topical administration of a parathyroid hormone-related protein agonist [parathyroid hormone-related protein (1-36)] and a parathyroid hormone-related protein antagonist [parathyroid hormone (7-34)] on the healing rate and morphology of the wounds.
"
Related Drugs and Biologics
1.
Amides
2.
Parathyroid Hormone-Related Protein
3.
Conditioned Culture Media
4.
Messenger RNA (mRNA)
5.
Peptides (Polypeptides)
6.
Parathyroid Hormone (Parathormone)
Related Therapies and Procedures
1.
Topical Administration