|1.||Vetvicka, Vaclav: 19 articles (02/2013 - 03/2002)|
|2.||Fusek, Martin: 14 articles (02/2013 - 03/2002)|
|3.||Vashishta, Aruna: 10 articles (04/2012 - 07/2006)|
|4.||Vetvickova, Jana: 7 articles (01/2011 - 03/2002)|
|5.||Ohri, Sujata Saraswat: 6 articles (12/2009 - 11/2006)|
|6.||Benes, Petr: 4 articles (10/2008 - 10/2002)|
|7.||Proctor, Mary: 4 articles (02/2008 - 11/2006)|
|8.||Saraswat-Ohri, Sujata: 3 articles (05/2011 - 07/2006)|
|9.||Laurent-Matha, Valérie: 2 articles (12/2012 - 07/2002)|
|10.||Vetvicka, V: 2 articles (01/2005 - 06/2000)|
02/10/2013 - "Lately, an increasing number of studies demonstrated that procathepsin D secreted from cancer cells, acts as a mitogen on cancer cells and stimulates their pro-invasive and pro-metastatic properties. "
05/01/2011 - "Recent studies have also implicated the possible use of procathepsin D/activation peptide as a marker of cancer progression. "
05/01/2011 - "Previous studies showed that the mitogenic effect of procathepsin D on cancer cells was mediated through its propeptide or activation peptide. "
12/01/2009 - "Additional studies suggested that procathepsin D/CD is an independent prognostic factor in various cancers, leading to the investigations of pCD/CD as a potential target for designing anti-cancer therapy. "
11/01/2013 - "Pro-Cathepsin D (pCD) is an aspartyl endopeptidase which is over expressed in many cancers. "
|2.||Breast Neoplasms (Breast Cancer)
07/01/2007 - "Depletion of procathepsin D gene expression by RNA interference: a potential therapeutic target for breast cancer."
05/01/2007 - "Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy."
07/28/2006 - "Effect of procathepsin D activation peptide on gene expression of breast cancer cells."
10/01/2002 - "Procathepsin D in breast cancer: what do we know? "
09/01/1998 - "We studied pro-cathepsin D endocytosis in two human breast cancer cell lines (MDA-MB231, MCF-7) and in human normal fibroblasts. "
|3.||Neoplasm Metastasis (Metastasis)
02/01/2008 - "Expression and secretion of procathepsin D (pCD) increases proliferation, metastasis and progression of breast cancer but the structural moiety by which pCD exerts these effects is still ambiguous. "
07/28/2006 - "Overexpression of procathepsin D (pCD) is reported to occur in numerous types of cancer and is associated with increased growth and metastasis. "
04/01/1994 - "We conclude that pro-cathepsin D overexpression facilitates tumor metastasis only when maturated into an active enzyme."
04/01/1994 - "While overexpressed cathepsin D increased experimental metastasis in athymic mice, the pro-cathepsin/D-KDEL was totally ineffective. "
01/01/1993 - "By contrast, Cox multiparametric analysis showed that pro-cathepsin D status had no prognostic value for survival, or metastasis free survival contrary to total cathepsin D status. "
06/01/2007 - "Procathepsin D (pCD), the precursor form of lysosomal aspartic protease, is overexpressed and secreted by various carcinomas. "
11/10/2010 - "Procathepsin D (pCD) is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas. "
08/07/1996 - "Data from the human colorectal derived adenoma to carcinoma sequence indicate that an in vivo mechanism may exist that, dependent on the simultaneous presence of both a tumour-generated acidic extracellular environment and an elevated secretion of procathepsin D, could result in the activation of latent procathepsin outside the cell."
12/08/2000 - "The seminal vesicle fluid from patients with prostate carcinoma contained the mature cathepsin D and procathepsin D, but not pseudocathepsin D, suggesting that pseudocathepsin D is not a normal intermediate of procathepsin D processing in vivo. "
12/08/2000 - "Since deglycosylated procathepsin D from both prostate and breast carcinoma cells exhibited a similar low angiostatin-generating activity, this discrepancy appeared to be attributed to the difference in carbohydrate structures of procathepsin D molecules between the two cell types. "
|5.||Ovarian Neoplasms (Ovarian Cancer)
08/01/1999 - "Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer."
12/01/1992 - "Estradiol stimulates cell growth and secretion of procathepsin D and a 120-kilodalton protein in the human ovarian cancer cell line BG-1."
01/01/1989 - "[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers]."
03/01/1998 - "These immunoglobulins are shown to be immunoreactive with both the 52-kDa procathepsin D and the 32-kDa mature cathepsin D derived from the UL-1 ovarian cancer cell line. "
|3.||Interleukin-10 (Interleukin 10)
|4.||Interleukin-4 (Interleukin 4)
|7.||Proteins (Proteins, Gene)
|9.||IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)