procathepsin D

04/01/2012 - "Procathepsin d involvement in chemoresistance of cancer cells."
11/10/2010 - "Procathepsin D and cancer: From molecular biology to clinical applications."
01/01/2005 - "For the past ten years, our research has been focused on elucidating the mechanism by which procathepsin D (pCD) impacts cancer development. "
01/01/2005 - "Possible role of procathepsin D in human cancer."
09/01/2004 - "Procathepsin D is over-secreted by some human cancer cells. "

07/01/2007 - "Depletion of procathepsin D gene expression by RNA interference: a potential therapeutic target for breast cancer."
10/01/2002 - "Procathepsin D in breast cancer: what do we know? "
09/01/1998 - "We studied pro-cathepsin D endocytosis in two human breast cancer cell lines (MDA-MB231, MCF-7) and in human normal fibroblasts. "
11/04/1997 - "Flow cytometry was used to test the binding of procathepsin D purified from the secretion of the breast cancer cell line ZR-75-1 to human breast cancer cells. "
04/01/1995 - "Elevated levels of pro-cathepsin-d in the plasma of breast-cancer patients."

02/01/2008 - "Expression and secretion of procathepsin D (pCD) increases proliferation, metastasis and progression of breast cancer but the structural moiety by which pCD exerts these effects is still ambiguous. "
07/28/2006 - "Overexpression of procathepsin D (pCD) is reported to occur in numerous types of cancer and is associated with increased growth and metastasis. "
04/01/1994 - "While overexpressed cathepsin D increased experimental metastasis in athymic mice, the pro-cathepsin/D-KDEL was totally ineffective. "
01/01/1993 - "By contrast, Cox multiparametric analysis showed that pro-cathepsin D status had no prognostic value for survival, or metastasis free survival contrary to total cathepsin D status. "
02/01/2012 - "Procathepsin D (pCD) is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas, affecting multiple features of tumor cells including proliferation, invasion, metastasis and apoptosis. "

08/31/2020 - "Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study."
08/31/2020 - "The aim of this study was to determine whether pro-cathepsin D can serve as a novel biomarker to discriminate between MPE and benign pleural effusion (BPE). "

11/10/2010 - "Procathepsin D (pCD) is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas. "
08/07/1996 - "Data from the human colorectal derived adenoma to carcinoma sequence indicate that an in vivo mechanism may exist that, dependent on the simultaneous presence of both a tumour-generated acidic extracellular environment and an elevated secretion of procathepsin D, could result in the activation of latent procathepsin outside the cell."
06/01/2007 - "Procathepsin D (pCD), the precursor form of lysosomal aspartic protease, is overexpressed and secreted by various carcinomas. "
12/08/2000 - "The seminal vesicle fluid from patients with prostate carcinoma contained the mature cathepsin D and procathepsin D, but not pseudocathepsin D, suggesting that pseudocathepsin D is not a normal intermediate of procathepsin D processing in vivo. "
02/01/2012 - "Procathepsin D (pCD) is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas, affecting multiple features of tumor cells including proliferation, invasion, metastasis and apoptosis. "