hypaconitine

RN given refers to the (1alpha,6alpha,14alpha,15alpha,16beta)-isomer

Also Known As:

hypaconitine hydrobromide; aconitane-8,13,14,15-tetrol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1alpha,6alpha,14alpha,15alpha,16beta)-

Networked: 16 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Diterpene Alkaloids: 19
        Aconitine: 466
        hypaconitine: 16
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Diterpene Alkaloids: 19
    - Aconitine: 466
      - hypaconitine: 16

Experts

1.	Wang, Liqin: 2 articles (06/2022 - 01/2016)
2.	Deng, Haiming: 1 article (06/2022)
3.	Qiao, Yun: 1 article (06/2022)
4.	Wang, Tengyu: 1 article (06/2022)
5.	Xiong, Mingfeng: 1 article (06/2022)
6.	Zhu, Jianbing: 1 article (06/2022)
7.	Fang, Chengxin: 1 article (05/2021)
8.	Guo, Li: 1 article (05/2021)
9.	Liu, Hongmei: 1 article (05/2021)
10.	Liu, Juanru: 1 article (05/2021)

Related Diseases

1.	Heart Failure 11/26/2023 - "The search was performed using specific keywords such as "hypaconitine," "heart failure," "anti-inflammatory," "aconite decoction," "pharmacological," "pharmacokinetics," "toxicity," "detoxification or toxicity reduction," and "extraction and isolation." The inclusion of these keywords ensured a comprehensive exploration of relevant studies and enabled the retrieval of valuable information pertaining to the various aspects of HA. " 06/16/2022 - "The present study aimed to determine the protective effects of hypaconitine (HA) and glycyrrhetinic acid (GA) against chronic heart failure (CHF) in the rats and to explore the underlying molecular mechanisms. " 06/16/2022 - "Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats." 01/01/2016 - "Hypaconitine (HA) and glycyrrhetinic acid (GA) are active components of Fuzi (Aconitum carmichaelii) and Gancao (Glycyrrhiza uralensis Fisch); they have been used in compatibility for chronic heart failure (CHF) from ancient times. "
2.	Cardiotoxicity 08/01/2019 - "Cardiac toxicity was assessed by measuring CK (creatine kinase) and LDH (lactate dehydrogenase) levels after hypaconitine administration to wild-type and Bmal1-/- (a clock disrupted model) mice at different times of day. " 05/01/2021 - "This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaconitine (HAC) and three monoester diterpene alkaloids (MDAs) including 14-α-benzoylaconine (BAC), 14-α-benzoylmesaconine (BMAC), 14-α-benzoylhypaconine (BHAC) on zebrafish. "
3.	Ulcerative Colitis 01/25/2011 - "Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid." 01/25/2011 - "In this study, we selected three alkaloids from FMP, namely, berberine, hypaconitine and skimmianine to study the individual drug effect and compare these results with the BHS combination on: 1) The recovery of ulcerative colitis rats induced by trinitrobenzene-sulfonic acid. "
4.	Inflammation (Inflammations) 01/01/2017 - "As a classic Traditional Chinese Medicine formula, Ephedra Aconite Asarum Decoction with the main ingredients of ephedrine and hypaconitine can show effect on anti-inflammation and immunoregulation. " 03/01/2014 - "We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2017 - "Hypaconitine is an active component of Aconitum carmichaelii Debx, a Chinese medicinal herb for the treatment of cardiovascular diseases, but the mechanism underlying its effect remains elusive. " 01/16/2015 - "Hypaconitine (HC) is one of the main aconitum alkaloids in Aconitum carmichaelii (AC), which is considered to be effective on cardiovascular disease, although it also has high toxicity. "

Related Drugs and Biologics

1.	Glycyrrhetinic Acid (Po 12)
2.	Aconitine
3.	mesaconitine
4.	Alkaloids
5.	Diterpene Alkaloids
6.	Sulfonic Acids
7.	Berberine
8.	skimmianine
9.	N-formylmethionylphenylalanine (FMP)
10.	Voltage-Gated Sodium Channels

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)