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carebastine

active carboxylic acid metablite of ebastine; structure given in first source

Also Known As:

Benzeneacetic acid, 4-(4-(4-(diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-alpha,alpha-dimethyl-

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Butyrophenones: 43
    - carebastine: 7
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - carebastine: 7

Experts

1.	Kamura, S: 1 article (09/2020)
2.	Kawasaki, H: 1 article (09/2020)
3.	Murashima, A: 1 article (09/2020)
4.	Ozawa, K: 1 article (09/2020)
5.	Sago, H: 1 article (09/2020)
6.	Saito, J: 1 article (09/2020)
7.	Sandaiji, N: 1 article (09/2020)
8.	Suzuki, T: 1 article (09/2020)
9.	Wada, S: 1 article (09/2020)
10.	Yagishita, S: 1 article (09/2020)

Related Diseases

1.	Polyps 01/01/1996 - "In this study we have investigated the effects of ebastine and carebastine on the release of eicosanoids and cytokines from human dispersed polyp cells and the effect of these compounds on the release of inflammatory mediators into nasal lavage fluid after allergen challenge. "
2.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 09/01/2000 - "In a multicenter, multinational, double-blind, randomized, placebo-controlled study, patients with seasonal allergic conjunctivitis (SAC) were assigned an eye drop formulation of carebastine (25 mg/ml) or placebo. "
3.	Allergic Rhinitis 03/01/2001 - "Ebastine is a potent and selective H1-receptor antagonist indicated for allergic rhinitis which undergoes extensive first pass metabolism by CYP3A4 to form an active metabolite, carebastine. " 09/01/2000 - "Carebastine, a histamine H1 antagonist, is under development by Almirall Prodesfarma for the potential treatment of allergic rhinitis, asthma and conjunctivitis. "
4.	Cardiotoxicity 02/28/2002 - "Active hydrophilic metabolites of the second-generation antihistaminic compounds (ebastine-carebastine, loratadine-desloratadine, terfenadine-fexofenadine, astemizole-norastemizole) are new compounds with probably reduced risk for drug interactions and cardiac toxicity."
5.	Airway Remodeling 10/01/2009 - "Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling."

Related Drugs and Biologics

1.	ebastine (Kestin)
2.	Cytokines
3.	Eicosanoids
4.	Ophthalmic Solutions (Eye Drops)
5.	Allergens
6.	Cytochrome P-450 CYP3A
7.	Loratadine (Alavert)
8.	Terfenadine (Seldane)
9.	Astemizole
10.	Histamine H1 Antagonists