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cyclopentenylcytosine 6-triphosphate

structure given in first source; inhibitor of CTP synthetase

Also Known As:

CPC TP; CPEC-TP; cyclopentenyl cytosine 5'-triphosphate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - Cytosine Nucleotides: 10
        Cytidine Triphosphate: 2076
        cyclopentenylcytosine 6-triphosphate: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Cytosine Nucleotides: 10
      - Cytidine Triphosphate: 2076
        cyclopentenylcytosine 6-triphosphate: 2
  - Pyrimidine Nucleotides: 48
    - Cytosine Nucleotides: 10
      - Cytidine Triphosphate: 2076
        cyclopentenylcytosine 6-triphosphate: 2

Related Diseases

1.	Neoplasms (Cancer) 08/15/1993 - "When CPEC-TP levels were measured in PBM cells from 12 cancer patients after 20 h continuous infusion of CPEC at doses ranging from 3.5 to 5.9 mg/m2/h, the levels attained ranged from 1.4 to 13.4 microM (3.6 to 33.5 pmol/10(7) cells). " 08/15/1993 - "Cyclopentenyl cytosine 5'-triphosphate (CPEC-TP) is the active metabolite of the investigational drug cyclopentenyl cytosine (CPEC), a nucleoside analogue which exhibits noteworthy antineoplastic activity against several murine and human tumors in tissue culture, and which is now undergoing Phase I clinical trials. "
2.	Glioma (Gliomas) 01/01/1997 - "Glioma cells obtained at surgery and in log phase growth were exposed to the drug at levels ranging from 0.01 to 1 microM for 24 h, and CPEC-TP and CTP levels were determined by HPLC. "

Related Drugs and Biologics

1.	cyclopentenylcytosine 6-triphosphate
2.	Investigational Drugs
3.	Nucleosides
4.	Cytidine Triphosphate (CTP)
5.	Antineoplastic Agents (Antineoplastics)
6.	cyclopentenyl cytosine
7.	phytobacteriomycin (PBM)