1,7- dioxa- 2,6- diaza- 4,7a- dithia- 3H,5H- benzo(cd)pentalene

09/01/2003 - "Experimental study on therapeutic effect of in vivo expression of Cell I-Hep II recombinant polypeptide of fibronectin on murine H22 hepatocellular carcinoma."

07/01/2006 - "Its Cell I-Hep II domain is potentially useful in tumor therapy. "
01/01/1997 - "The presence and connection of cell I and Hep II domains are the elements which determine the ability of recombinant FN polypeptides to inhibit the metastasis of tumor cells."
01/22/2016 - "Antibody specific for the Hep-II heparin-binding domain of fibronectin blocks exosome interaction with tumor cells or with marrow stromal cells. "
01/01/2017 - "The heparin binding site (Hep II) of fibronectin plays a major role in tumor cell metastasis. "
01/01/2001 - "To construct an eukaryotic expressing vector that expresses CH50, a recombinant Cell I-Hep II bifunctional-domain polypeptide of human fibronectin, and to investigate the chemotaxis to immune cells and the inhibitory effect on the growth of tumor by the expression of the plasmid in vivo, the plasmid was constructed by DNA recombination. "

02/01/1996 - "The C-terminal heparin-binding domain of FN (Hep II) has recently been demonstrated to support adhesion of alpha 4 beta 1-dependent melanoma cells [A. "
03/01/1993 - "Mouse melanoma cells utilise an additional cell-binding site in the Hep II domain of FN and their preference for FN coated on TCPS was less marked than that of BHK cells. "
01/01/2017 - "Human melanoma inhibitory protein binds to the FN12-14 Hep II domain of fibronectin."
08/01/1992 - "Melanoma cellular receptor(s) for the Hep II region may be cell surface proteoglycans but do not appear to bind to areas of Hep II with high affinity for soluble heparin, as the latter was not an inhibitor of B16 cell adhesion to the HBF. "
10/23/2018 - "Fibronectin is a large multidomain protein of the extracellular matrix that harbors two heparin binding sites, Hep-I and Hep-II, which support the heparin-dependent adhesion of melanoma and neuroblastoma cells [Barkalow, F. "

01/01/1997 - "The presence and connection of cell I and Hep II domains are the elements which determine the ability of recombinant FN polypeptides to inhibit the metastasis of tumor cells."
01/01/2017 - "The heparin binding site (Hep II) of fibronectin plays a major role in tumor cell metastasis. "

12/08/2020 - "pneumoniae corneal infection by binding to the Hep II domain and interfering with S. "
09/02/2008 - "Surfen also blocked heparan sulfate-mediated cell adhesion to the Hep-II domain of fibronectin and prevented infection by HSV-1 that depended on glycoprotein D interaction with heparan sulfate. "