McN 5652

only McN 5662-X-68 (6S,10R-enantiomer) is biologically active; structure given in first source

Also Known As:

MCN-5652Z68; McN 5652-X-68; McN-5652; McN-5652-Z; McN-5652-Z-68; Pyrrolo(2,1-a)isoquinoline, 1,2,3,5,6,10b-hexahydro-6-(4-(methylthio)phenyl)-, (6R,10bS)-

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - McN 5652: 4

Experts

1.	Huang, Yiyun: 2 articles (01/2006 - 12/2002)
2.	Van Heertum, Ronald L: 2 articles (01/2006 - 12/2002)
3.	Abi-Dargham, Anissa: 2 articles (12/2003 - 12/2002)
4.	Laruelle, Marc: 2 articles (12/2003 - 12/2002)
5.	Lombardo, Ilise: 2 articles (12/2003 - 12/2002)
6.	Slifstein, Mark: 2 articles (12/2003 - 12/2002)
7.	Arango, Victoria: 1 article (01/2006)
8.	Arcement, Julie: 1 article (01/2006)
9.	Hastings, Ramin S: 1 article (01/2006)
10.	Huang, Yung-yu: 1 article (01/2006)

Related Diseases

1.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 12/15/2003 - "Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652."
2.	Social Phobia 12/01/2002 - "Measures of SERT availability were obtained with positron emission tomography and the SERT radiotracer [(11)C](+)-McN 5652 in five patients with social phobia before and during treatment with paroxetine at usual therapeutic doses (20-40 mg per day). " 12/01/2002 - "Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652."
3.	Major Depressive Disorder (Major Depressive Disorders) 01/01/2006 - "Serotonin transporter binding potential (f(1)B(max)/K(d)) was determined using positron emission tomography with [(11)C]McN 5652 in six brain regions in 25 medication-free subjects with DSM-IV major depressive disorder during a major depressive episode and in 43 healthy volunteer comparison subjects. "
4.	Hyperthermia 04/10/1991 - "Both the behavioral syndrome and hyperthermia produced by (+)-McN-5652-Z were counteracted by parachlorophenylalanine or ketanserin. " 04/10/1991 - "forepaw treading, retropulsion and splayed hindlimbs) as well as hyperthermia occurred after bilateral injection of the (6S, 10bR)-(+)-enantiomer of McN-5652-Z into the cerebral ventricles in pargyline-treated rats. "

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Paroxetine (Paxil)
3.	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)
4.	Pargyline (Pargyline Hydrochloride)
5.	Ketanserin