pradimicin A

from actinomycete strain No. P157-2; has inhibitory effect against HIV in vitro; structure given in first source

Also Known As:

BMY 28567; BMY-28567; D-Alanine, N-((5-((4,6-dideoxy-4-(methylamino)-3-O-beta-D-xylopyranosyl-beta-D-galactopyranosyl)oxy)-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenz(a)naphthacen-2-yl)carbonyl)-, (5S-trans)-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Balzarini, Jan: 1 article (01/2007)
2.	Bugatti, Antonella: 1 article (01/2007)
3.	Daelemans, Dirk: 1 article (01/2007)
4.	Hatse, Sigrid: 1 article (01/2007)
5.	Igarashi, Yasuhiro: 1 article (01/2007)
6.	Oki, Toshikazu: 1 article (01/2007)
7.	Rusnati, Marco: 1 article (01/2007)
8.	Schols, Dominique: 1 article (01/2007)
9.	Van Laethem, Kristel: 1 article (01/2007)

Related Diseases

1.	Infections 06/01/1990 - "The data indicate that (1) preincubation of the cells with HIV at 0 degrees for 1 hr, followed by the addition of pradimicin A and further incubation at 37 degrees, resulted in a complete inhibition of infection while preincubation at 37 degrees did not. " 01/01/2007 - "Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus." 09/01/1995 - "Pradimicin A, an antifungal antibiotic isolated from Actinomadura hibisca, and the derivative BMY-28864 have the ability to inhibit HIV-1 infection in vitro. "
2.	Paramyxoviridae Infections (Parainfluenza) 10/01/1997 - "Enhancement of human parainfluenza virus-induced cell fusion by pradimicin, a low molecular weight mannose-binding antibiotic."
3.	HIV Infections (HIV Infection) 06/01/1990 - "The mechanism of action of a novel anti-HIV antibiotic, pradimicin A, has been studied using cell-free (MT-4 cells) and cell to cell (MOLT-4 and MOLT-4/HIVHTLV-3B cells) HIV infection systems. " 06/01/1990 - "These data imply that pradimicin A inhibits an early step in HIV infection, probably through its binding to mannose residues of HIV glycoprotein." 06/01/1990 - "(3) The inhibitory effect of pradimicin A on HIV infection was prevented by mannan but not by other sugars tested. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Mannose (D-Mannose)
3.	Mannans
4.	Glycoproteins (Glycoprotein)
5.	Carbohydrates
6.	Sugars
7.	N,N-dimethylpradimicin FA-2