glycylprolyl-4-methylcoumaryl-7-amide

Also Known As:

Gly-Pro-4-methylcoumaryl-7-amide; Gly-Pro-MCA

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        glycylprolyl-4-methylcoumaryl-7-amide: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        glycylprolyl-4-methylcoumaryl-7-amide: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - glycylprolyl-4-methylcoumaryl-7-amide: 3

Related Diseases

1.	Osteoporosis 12/01/1988 - "In contrast, the activity of post-proline cleaving enzyme (PPCE) was not increased in serum from patients with osteoporosis, as determined with succinyl-Gly-Pro-4-methylcoumaryl-7-amide (Suc-Gly-Pro-MCA) as substrate. "
2.	Carcinoma (Carcinomatosis) 05/01/1987 - "The separation and characterization of Gly-Pro-MCA hydrolases by gel filtration, affinity chromatography, and substrate specificity demonstrated that HF have three peaks indicating DPP IV, DPP II, and an unknown enzyme, whereas the three carcinoma cell lines gave a prominent peak indicating DPP II and a trace of DPP IV. The DPP II activity was 6- to 24-fold higher in carcinoma cell lines than in HF, and it also was 2.85- to 4.13-fold higher than the DPP IV activity in carcinoma cell lines but was 10-fold lower in HF. " 05/01/1987 - "Examination of carcinoma cells for the subcellular localization and pH optimum of Gly-Pro-MCA hydrolase activity revealed that the activity of a lysosomal enzyme that hydrolyzes Gly-Pro-MCA at pH 6.4 was markedly increased in carcinoma cells, but not in normal cells. " 05/01/1987 - "The homogenates of three carcinoma cell lines (HeLa, KB, and K-44) contained lower glycylprolyl methylcoumarinamide (Gly-Pro-MCA) hydrolase activities at pH 8.7 (assumed to be DPP IV) and higher activities of alkaline phosphatase and gamma-glutamyl transpeptidase, which are also membrane-bound enzymes, than those of normal human fibroblasts (HF). "
3.	Squamous Cell Carcinoma of Head and Neck 09/15/1989 - "Serum glycyl-l-prolyl 4-methyl-coumaryl-7-amide (gly-pro-MCA) hydrolase (DPP IV) and L-lysyl-L-alanyl beta-naphthylamide (lys-ala-beta NA) hydrolase (assumed to be DPP II) activities were measured in patients with oral squamous cell carcinoma and healthy subjects. "

Related Drugs and Biologics

1.	Hydrolases
2.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)
3.	Enzymes
4.	Alkaline Phosphatase
5.	Prolyl Oligopeptidases
6.	4-methyl-coumaryl-7-amide
7.	2-naphthylamide
8.	lysyl-alanyl-beta-naphthylamide