HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

4,4'- (2,2- bis((4- (aminoiminomethyl)- 2- bromophenoxy)methyl)- 1,3- propanediyl)bis(oxy))bis(3- bromobenzenecarboximidamide

structure given in first source

Also Known As:

TAPP-Br

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Benzamidines: 5
    - 4,4'-(2,2-bis((4-(aminoiminomethyl)-2-bromophenoxy)methyl)-1,3-propanediyl)bis(oxy))bis(3-bromobenzenecarboximidamide: 4

Related Diseases

1.	Neoplasms (Cancer) 11/01/1989 - "Mice treated with TAPP-Br on the other hand did not develop sizable tumors or consistently developed tumors of significantly smaller sizes. " 11/17/1992 - "In the present study are reported the differential DNA binding activity of the anti-tumor polyamidine tetra-p-amidinophenoxyneopentane (TAPP-H) and its 2'-halo derivative (TAPP-Br), and their effects on the binding of the recombinant Epstein-Barr virus (EBV) nuclear antigen to a synthetic oligonucleotide mimicking the target DNA sequence present in the EBV genome. "
2.	Melanoma (Melanoma, Malignant) 11/01/1989 - "5 X 10(6) melanoma cells were injected subcutaneously in groups of nude mice and treatment with TAPP-Br was performed (0.125-1 mg/0.2 ml injections, repeated three times at the beginning of the experiment and after 20 days). " 11/01/1989 - "An aromatic poly-amidine (tetra-p-amidinophenoxyneopentane, TAPP-Br) exhibiting anti-proteinase activity and known to exert antitumor activity in vitro was analysed for its ability to inhibit the in vivo growth of a human melanoma cell line transplanted in nude mice. " 08/01/1990 - "Apart from its antiproteinase activity, the aromatic polyamidine TAPP-Br [the bromo derivative of 1,3-di-(p-amidinophenoxy)-2,2-bis-(p-amidinophenoxymethyl)propane (TAPP-H)] is able to inhibit the in vitro growth of a variety of tumor cell lines, including human melanoma, and breast and kidney carcinoma. "
3.	Carcinoma (Carcinomatosis) 07/01/1992 - "TAPP-Br inhibited the cell growth of all the colon carcinoma cell lines, and this effect was irreversible. " 08/01/1990 - "Apart from its antiproteinase activity, the aromatic polyamidine TAPP-Br [the bromo derivative of 1,3-di-(p-amidinophenoxy)-2,2-bis-(p-amidinophenoxymethyl)propane (TAPP-H)] is able to inhibit the in vitro growth of a variety of tumor cell lines, including human melanoma, and breast and kidney carcinoma. " 07/01/1992 - "These findings overall suggest that the serine protease inhibitor, TAPP-Br, might inhibit the cell growth of colon carcinoma cell lines through suppressing the expression of genes whose promoter contains a 12-O-tetradecanoylphorbol-13-acetate-responsive element or serum-responsive element." 07/01/1992 - "The inhibitory effect of a serine protease-inhibiting tetra-benzamidine derivative, TAPP-Br, on the cell growth of 8 human colon carcinoma cell lines was examined and the mechanism of the inhibition was analyzed. "
4.	Leukemia 11/17/1992 - "In addition, the proliferation kinetics and cell cycle analysis of human leukemia K562 cells treated with TAPP-H and TAPP-Br are reported. "

Related Drugs and Biologics

1.	1,3- di- (4- amidinophenoxy)- 2,2- bis- (4- amidinophenoxymethyl)propane
2.	Epstein-Barr Virus Nuclear Antigens
3.	Oligonucleotides
4.	DNA (Deoxyribonucleic Acid)
5.	Serine Proteases (Serine Protease)
6.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
7.	Peptide Hydrolases (Proteases)
8.	Elements
9.	benzamidine

Related Therapies and Procedures

1.	Injections