1,3- di- (4- amidinophenoxy)- 2,2- bis- (4- amidinophenoxymethyl)propane

RN given refers to parent cpd; structure given in first source

Also Known As:

1,3-bis(p-amidinophenoxy)-2,2-bis(p-amidinophenoxymethyl)propane; 1,3-di-(4-amidinophenoxy)-2,2-bis-(4-amidinophenoxymethyl)propane hydrochloride; 1,3-di-(p-amidinophenoxy)-2,2-bis(p-amidinophenoxymethyl)-propane; 4,4'-((2,2-bis((4-(aminoiminomethyl)phenoxy)methyl)-1,3-propanediyl)bis(oxy))bisbenzenecarboximidamide; TAPNP; TAPP-H; tetra-4-amidinophenoxyneopentane; tetra-p-amidinophenoxy-neo-pentane

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Benzamidines: 5
    - 1,3-di-(4-amidinophenoxy)-2,2-bis-(4-amidinophenoxymethyl)propane: 3

Related Diseases

1.	Neoplasms (Cancer) 11/17/1992 - "In the present study are reported the differential DNA binding activity of the anti-tumor polyamidine tetra-p-amidinophenoxyneopentane (TAPP-H) and its 2'-halo derivative (TAPP-Br), and their effects on the binding of the recombinant Epstein-Barr virus (EBV) nuclear antigen to a synthetic oligonucleotide mimicking the target DNA sequence present in the EBV genome. " 06/01/1986 - "Moreover, the data reported here allowed us to clarify the inhibition mechanism (in vitro) of TAPP-H on blood coagulation, induced by the "cancer coagulation factor" produced by the Walker carcinoma in Wistar rats and on the fibrinogen-to-fibrin conversion, and to identify some serine proteinases which act as targets for aromatic tetra-amidines."
2.	Carcinoma (Carcinomatosis) 08/01/1990 - "Apart from its antiproteinase activity, the aromatic polyamidine TAPP-Br [the bromo derivative of 1,3-di-(p-amidinophenoxy)-2,2-bis-(p-amidinophenoxymethyl)propane (TAPP-H)] is able to inhibit the in vitro growth of a variety of tumor cell lines, including human melanoma, and breast and kidney carcinoma. " 06/01/1986 - "Moreover, the data reported here allowed us to clarify the inhibition mechanism (in vitro) of TAPP-H on blood coagulation, induced by the "cancer coagulation factor" produced by the Walker carcinoma in Wistar rats and on the fibrinogen-to-fibrin conversion, and to identify some serine proteinases which act as targets for aromatic tetra-amidines."
3.	Melanoma (Melanoma, Malignant) 08/01/1990 - "Apart from its antiproteinase activity, the aromatic polyamidine TAPP-Br [the bromo derivative of 1,3-di-(p-amidinophenoxy)-2,2-bis-(p-amidinophenoxymethyl)propane (TAPP-H)] is able to inhibit the in vitro growth of a variety of tumor cell lines, including human melanoma, and breast and kidney carcinoma. "
4.	Leukemia 11/17/1992 - "In addition, the proliferation kinetics and cell cycle analysis of human leukemia K562 cells treated with TAPP-H and TAPP-Br are reported. "

Related Drugs and Biologics

1.	4,4'- (2,2- bis((4- (aminoiminomethyl)- 2- bromophenoxy)methyl)- 1,3- propanediyl)bis(oxy))bis(3- bromobenzenecarboximidamide
2.	Epstein-Barr Virus Nuclear Antigens
3.	Oligonucleotides
4.	DNA (Deoxyribonucleic Acid)
5.	Serine Proteases (Serine Protease)
6.	Fibrinogen (Factor I)
7.	Fibrin
8.	Blood Coagulation Factors (Coagulation Factor)
9.	Amidines