|1.||Takumi, Shota: 4 articles (03/2015 - 06/2007)|
|2.||Furukawa, Tatsuhiko: 4 articles (03/2015 - 06/2007)|
|3.||Komatsu, Masaharu: 4 articles (03/2015 - 06/2007)|
|4.||Xie, Ping: 4 articles (05/2014 - 01/2009)|
|5.||Yang, Liuyan: 4 articles (08/2013 - 12/2010)|
|6.||Filipic, Metka: 4 articles (09/2008 - 01/2003)|
|7.||Zegura, Bojana: 4 articles (09/2008 - 01/2003)|
|8.||Chen, Jun: 3 articles (01/2015 - 09/2012)|
|9.||Li, Guangyu: 3 articles (01/2015 - 01/2009)|
|10.||Wang, Ting: 3 articles (08/2013 - 03/2012)|
05/07/2014 - "Previous studies have demonstrated that Microcystin-LR is a potential carcinogen for animals and humans, and the International Agency for Research on Cancer has classified Microcystin-LR as a possible human carcinogen. "
03/01/2001 - "In this paper we tried to study the carcinogenic and tumor promotion mechanism of Microcystin LR (MCLR). "
12/04/2014 - "Understanding the mechanism of microcystin-LR toxicity is important, because of the both potencies of its acute cytotoxicity and tumor-promoting activity in hepatocytes of animals and humans. "
10/01/2014 - "Cyanobacteria-derived toxin microcystin-LR (MCLR) has been widely investigated in its effects on normal cells, there is little information concerning its effects on cancer cells. "
09/01/2012 - "Microcystin-LR (MCLR) is a widespread cyanotoxin produced in algal blooms, and has potent hepatotoxicity and tumor-promoting activity. "
|2.||Body Weight (Weight, Body)
05/23/2013 - "In the present study, Balb/c mice were intraperitoneally injected with microcystin-LR (MC-LR) at the doses of 0.5, 2 and 8 μg/kg body weight (bw) every 48 h for 30 d. "
06/01/2014 - "For this purpose, mice were intraperitoneally injected with 45 μg of MCYST-LR/kg body weight. "
08/12/2006 - "rubescens culture, at a density of 80,000 cells per 120 microl, was applied to coregonids thus corresponding to 0.6-0.9 microg microcystin-LR(equiv.)/kg body weight. "
12/15/2004 - "Toxic effects of microcystin-LR were studied in hepatocytes isolated from fed and fasted juvenile goldfish Carassius auratus (30 g body weight). "
03/01/2004 - "Fed and fasted juvenile goldfish Carassius auratus (30 g body weight) were injected intraperitoneally (i.p.) with microcystin-LR (MC-LR) (125 microg/kg body weight) to determine the effect of alimentary status on the hepatic toxicity of MC-LR. "
|3.||Melanoma (Melanoma, Malignant)
10/16/2012 - "This study indicates that microcystin-LR can act as a NF-κB activator to promote MMP-2/-9 expression and melanoma cell invasion, which deserves more environmental health concerns."
10/16/2012 - "Boyden chamber assay showed that microcystin-LR exposure (>12.5 nM) evidently enhanced the invasion ability of the melanoma cells (MDA-MB-435). "
08/06/2013 - "In this study, in vitro and in vivo experiments were conducted to investigate the effect of microcystin-LR on invasion and metastasis of human melanoma cells, and the underlying molecular mechanism was also explored. "
08/06/2013 - "Recently, we have indicated that microcystin-LR, a cyanobacterial toxin produced in eutrophic lakes or reservoirs, can increase invasive ability of melanoma MDA-MB-435 cells; however, the stimulatory effect needs identification by in vivo experiment and the related molecular mechanism is poorly understood. "
10/16/2012 - "Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/-9 expression mediated by NF-κB activation."
03/01/2015 - "We tried to establish the chemical prevention of microcystin-LR poisoning. "
12/01/2009 - "An antibody to the microcystin-LR (MC-LR), one of the common culprits in mass poisonings, was dispersed together with SWNTs. "
12/01/2004 - "Protective efficacy and the recovery profile of certain chemoprotectants against lethal poisoning by microcystin-LR in mice."
09/01/2010 - "Results of this study may contribute to the development of chemoprevention and chemotherapeutic approaches to microcystin-LR poisoning."
11/01/2001 - "pulicaria, using the mutant (MRC) and its' wild type (MRD), showed for the first time that microcystins other than microcystin-LR can be responsible for the poisoning of Daphnia by Microcystis. "
|5.||Hepatocellular Carcinoma (Hepatoma)
10/01/2015 - "Different responses of primary normal human hepatocytes and human hepatoma cells toward cyanobacterial hepatotoxin microcystin-LR."
12/10/2006 - "Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells."
01/01/2003 - "Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2."
01/01/2003 - "In this study we demonstrate that microcystin-LR (MCLR) at doses that were not cytotoxic (0.01-1 microg/ml), induced dose and time dependent DNA strand breaks in human hepatoma cell line HepG2. "
07/15/2004 - "With the comet assay we demonstrate that, in human hepatoma HepG2 cells, microcystin-LR (MCLR) induced DNA strand breaks which were transiently present and probably produced during the cellular repair of MCLR-induced DNA damage. "
|2.||DNA (Deoxyribonucleic Acid)
|4.||Messenger RNA (mRNA)
|6.||Cytochrome P-450 CYP2E1 (CYP2E1)
|7.||Cytochrome P-450 CYP1A1 (CYP1A1)
|10.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|5.||Heterologous Transplantation (Xenotransplantation)