N- Ac- 2- Nal(1)- 4- Cl- Phe(2)- 3- Pal(3)- Arg(5)- Glu(6)- AlaNH2(10)- LHRH

gonadorelin antagonist

Also Known As:

LHRH, N-Ac-2-Nal(1)-4-Cl-Phe(2)-3-Pal(3)-Arg(5)-Glu(6)-AlaNH2(10)-; GnRH, N-Ac-2-Nal(1)-4-Cl-Phe(2)-3-Arg(5)-Glu(6)-AlaNH2(10)-NH2(10)-; LHRH, N-Ac-2-naphthyl-Ala(1) 4-chloro-Phe(2)-3-pyridyl-Ala(3)-Arg(5)-Glu(6)-AlaNH2(10)-; LHRH, N-acetyl 2-naphthylalanyl(1)-4-chlorophenylalanyl(2)-3-pyridylalanyl(3)-arginyl(5)-glutamyl(6)-alaninamide(10)-; Nal-Glu-GnRH; Nal-Glu-GnRHant; NalGlu peptide

Networked: 6 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Adenoma (Adenomas) 05/01/1993 - "When Nal-Glu GnRH (5 mg, sc, every 12 h) was self-administered for 3-12 months to five men with gonadotroph adenomas and supra-normal serum FSH concentrations, the serum FSH concentrations decreased to normal or below normal for the entire treatment period. " 05/01/1993 - "To quantitate the effect of Nal-Glu GnRH on gonadotroph adenoma size, we first developed a technique for calculating adenoma volume. " 05/01/1993 - "We conclude that calculating pituitary adenoma volume from MR data using the Softvu computer program is a highly reproducible technique, but that Nal-Glu GnRH is not an effective treatment for reducing gonadotroph adenoma size. " 02/01/1994 - "We therefore evaluated responses to the GnRH antagonist Nal-Glu-GnRH and to the long-acting GnRH agonist D-Trp6 (3.75 mg IM) in 9 and 4 patients with FSH- and/or alpha-subunit-secreting adenomas, respectively. " 07/01/1990 - "We conclude that repetitive administration of Nal-Glu GnRH may often inhibit FSH secretion by gonadotroph adenomas and that FSH secretion by gonadotroph adenomas may be dependent on endogenous GnRH secretion."
2.	Pituitary Neoplasms (Pituitary Adenoma) 05/01/1993 - "We conclude that calculating pituitary adenoma volume from MR data using the Softvu computer program is a highly reproducible technique, but that Nal-Glu GnRH is not an effective treatment for reducing gonadotroph adenoma size. "
3.	Leiomyoma (Uterine Fibroids) 10/01/1993 - "The efficacy of acute and sustained pituitary gonadotropin down-regulation by the Nal-Glu GnRH antagonist (Nal-Glu) was evaluated in the treatment of uterine leiomyomas. "
4.	Azoospermia 10/01/1998 - "In this study, 15 healthy men (age 21-41 yr) with normal semen analyses were treated with T enanthate (TE) 100 mg im/week plus 10 mg Nal-Glu GnRH antagonist sc daily for 12 weeks to induce azoospermia or severe oligozoospermia. "
5.	Oligospermia (Oligozoospermia) 10/01/1998 - "In this study, 15 healthy men (age 21-41 yr) with normal semen analyses were treated with T enanthate (TE) 100 mg im/week plus 10 mg Nal-Glu GnRH antagonist sc daily for 12 weeks to induce azoospermia or severe oligozoospermia. "

Related Drugs and Biologics

1.	2-naphthylalanyl-glutamic acid
2.	Gonadotropins
3.	Gonadotropin-Releasing Hormone (GnRH)