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nuclear CB antigen

MW 40 kDa; expressed in lymphoid cells of patients with autoimmune and non-autoimmune diseases

Also Known As:

CB antigen, nuclear; CB antigen; CB nuclear antigen

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Antigens: 143924
  - Autoantigens: 7570
    - nuclear CB antigen: 1
  - Nuclear Antigens: 1661
    - nuclear CB antigen: 1
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nuclear Proteins: 2678
    - Nuclear Antigens: 1661
      - nuclear CB antigen: 1

Experts

1.	Berneman, Zwi: 1 article (01/2009)
2.	Deckmyn, Hans: 1 article (01/2009)
3.	Gadisseur, Alain: 1 article (01/2009)
4.	Hermans, Cedric: 1 article (01/2009)
5.	Michiels, Jan Jacques: 1 article (01/2009)
6.	Schroyens, Wilfried: 1 article (01/2009)

Related Diseases

1.

von Willebrand Diseases (von Willebrand's Disease)

01/01/2009 - "A complete set of laboratory investigations, including bleeding time, PFA-100 closure times, factor VIII (FVIII) coagulant activity (FVIII:C), von Willebrand factor (VWF) ristocetin cofactor (VWF:RCo), collagen binding (VWF:CB), antigen (VWF:Ag) and propeptide (VWFpp), ristocetin-induced platelet aggregation (RIPA), multimeric analysis of VWF and the response of FVIII:C and VWF parameters to desmopressin (DDAVP), is necessary to fully diagnose all variants of von Willebrand disease (VWD) and to discriminate between type 1 and type 2 and between severe VWD type 1 and type 3. The response to DDAVP of VWF parameters is normal in pseudo VWD (mild VWF deficiency due to blood group O), in mild VWD type 1 and in carriers of recessive severe VWD type 1 and 3. The response to DDAVP is rather good but restricted followed by increased clearance in dominant type 1/2E, good but transient in mild type 2A group II, good for VWF:CB, with only poor response for VWF:RCo in 2M and 2U, poor in 2A group I, 2B, 2C and 2D, and very poor or non-responsive in severe recessive VWD type 1 and 3. Homozygosity or double heterozygosity for nonsense (null) mutations in the VWF gene result in recessive VWD type 3. The combination of a nonsense and missense mutation or of two missense mutations (homozygous or double heterozygous) may cause recessive severe VWD type 1. Recessive VWD type 2A subtype IIC (2C) is caused by homozygous or double heterozygous gene defects in the D1-D2 domain. "

Related Drugs and Biologics

1.	von Willebrand Factor
2.	Ristocetin
3.	Factor VIII (Coagulation Factor VIII)
4.	Deamino Arginine Vasopressin (Desmopressin)
5.	Collagen
6.	Coagulants
7.	Blood Group Antigens (Blood Groups)