|1.||Wohlfart, Stefanie: 1 article (08/2011)|
|2.||Kreuter, Jörg: 1 article (08/2011)|
|3.||Michaelis, Martin: 1 article (08/2011)|
|4.||Glatzel, Markus: 1 article (08/2011)|
|5.||Cinatl, Jindrich: 1 article (08/2011)|
|6.||Bernreuther, Christian: 1 article (08/2011)|
|7.||Khalansky, Alexander S: 1 article (08/2011)|
|8.||Opolon, P: 1 article (10/2006)|
|9.||Soria, C: 1 article (10/2006)|
|10.||Malvy, C: 1 article (10/2006)|
05/01/2005 - "These promising data showing a higher anti-tumor efficacy on HCC of PIHCA-Dox versus Dox, warrant further studies in both animals and humans."
08/01/1992 - "We have conducted a phase I clinical trial of DXR-PIHCA in 21 patients with refractory solid tumors (10 male, 11 female, median age: 53 years, median PS: 1, prior free-DXR therapy: 7 patients). "
08/04/1992 - "We have demonstrated that in vitro resistance of tumor cells to doxorubicin (Dox) can be fully circumvented by using doxorubicin-loaded nanospheres (Dox-NS), consisting of biodegradable polyisohexylcyanoacrylate polymers of 300 nm diameter and containing 2.83 mg of Dox per 31.5 mg of polymer. "
05/01/2005 - "Here, we compared in vitro and in vivo the anti-tumor efficacy of doxorubicin-loaded polyisohexylcyanoacrylate nanoparticles (PIHCA-Dox) versus free doxorubicin (Dox). "
10/01/2006 - "This study reports the efficacy and lack of toxicity of intravenously administered encapsulated anti-RhoA siRNA in chitosan-coated polyisohexylcyanoacrylate (PIHCA) nanoparticles in xenografted aggressive breast cancers (MDA-MB-231). "
|2.||Visceral Leishmaniasis (Kala Azar)
01/01/1989 - "The preparation and physico-chemical characterization of lyophilized polyisohexylcyanoacrylate nanoparticles loaded with dehydroemetine (DHE) for the treatment of visceral leishmaniasis disease is described. "
02/01/1992 - "The efficacy of primaquine-loaded polyisohexylcyanoacrylate (PIHCA) nanoparticles was evaluated using J774G8 macrophage-like cells infected with Leishmania donovani: as an in vitro model of visceral leishmaniasis. "
|3.||Neoplasm Metastasis (Metastasis)
09/01/1989 - "The sharp increase in the therapeutic index of ampicillin after linkage to PIHCA nanoparticles was explained by studies of the distribution of ampicillin, which showed that when bound to nanoparticles, the ampicillin was concentrated mainly in the liver and spleen, the primary foci of infection in the experimental model that we used. "
|5.||Glioblastoma (Glioblastoma Multiforme)
08/30/2011 - "The physico-chemical properties and the release of doxorubicin from the PIHCA-nanoparticles were analysed, and the influence on cell viability of the rat glioblastoma 101/8-cell line was investigated. "
01/01/1994 - "We have studied the cytotoxicity and accumulation of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres in a model of doxorubicin-resistant rat glioblastoma variants differing by their degree of resistance to this drug. "
08/30/2011 - "For this reason, polysorbate 80 (Tween 80)-coated poly(isohexyl cyanoacrylate) (PIHCA) (Monorex) nanoparticles loaded with doxorubicin were developed and tested for their use for the treatment of glioblastomas. "
|5.||Small Interfering RNA (siRNA)
|2.||Drug Therapy (Chemotherapy)