carbovir

Subscribe to Selected New Research on carbovir

11 relevant articles (3 outcomes, 0 trials/studies) found for this Bio-Agent

Description: structure given in first source; potent & selective anti-HIV agent

Also Known As:

2',3'-didehydro-2',3'-dideoxyguanosine; NSC 614846; NSC-614846

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1

Nucleosides: 591

Deoxyribonucleosides: 28

Dideoxynucleosides: 27

carbovir: 11

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS) 10/23/1990 - "Carbovir (CBV) is a highly selective carbocyclic nucleoside inhibitor of HIV replication in human lymphocytes and is potentially useful in the treatment of AIDS [Vince et al. (1988) Biochem" 02/01/1989 - "Carbovir is a novel carbocyclic nucleoside which has been shown to have potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome" 10/31/1988 - "Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients." 04/14/1989 - "Carbovir is a novel carbocyclic guanosine derivative that has potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome (AIDS)" 02/25/1992 - "Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (carbovir, NSC 614846) is an anti-retroviral agent that may be useful in the treatment of AIDS" Get all the results and reference details, order at left...
2.	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 05/23/2003 - "Mutation of Tyr955 in pol gamma causes the degenerative disease progressive external ophthalmoplegia in humans, and we show that this residue partially accounts for the ability of pol gamma to incorporate D4T-MP and carbovir" Get all the results and reference details, order at left...
3.	Infection 01/25/1991 - "Given the potent activity of carbovir-TP against HIV-1 reverse transcriptase and its lack of activity against human DNA polymerases, we believe that further evaluation of this compound as a potential drug for the treatment of HIV-1 infection is warranted." Get all the results and reference details, order at left...
4.	Hepatocellular Carcinoma (Hepatoma) 02/01/2001 - "We investigated the replication fitness and susceptibility of the wild-type and five mutant HBVs (L528M, M552I, M552V, L528M/M552I, and L528M/M552V) to 11 compounds [lamivudine, adefovir, entecavir (BMS-200475) (+)-BCH-189 (+/-)-FTC (racivir) (-)-FTC (emtricitabine) (+)-FTC, L-D4FC, L-FMAU (clevudine), D-DAPD, and (-)-carbovir] by transfecting HBV DNA into hepatoma cells and monitoring viral products by Southern blotting" Get all the results and reference details, order at left...
5.	Body Weight (Weight, Body) 02/01/1989 - "Six rats received carbovir (20 mg/kg of body weight) through the jugular vein, and blood samples were collected through the femoral vein 2, 5, 10, 15, 20, 30, 45, 60, 75, 90, 120, 150, 180, and 240 min after the dose" Get all the results and reference details, order at left...
5 Diseases and 11 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	carbovir
2.	Lamivudine (3TC)
3.	Guanosine
4.	DNA-Directed DNA Polymerase (Polymerases, DNA)
5.	DNA (Deoxyribonucleic Acid)
6.	Human immunodeficiency virus 1 reverse transcriptase
7.	entecavir
8.	emtricitabine (Emtriva)
9.	2',3'-dideoxy-2',3'-didehydrothymidine monophosphate
10.	2',3'-dideoxy-5-fluoro-3'-thiacytidine
12 Drugs and Important Bio-Agents and 8 more articles analyzed in the Research Interface, order at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License details >>

Price:

$490.00 access via web interface, 1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m", 1 year subscription

Proceed to Checkout >>