5-fluoromethylornithine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Borri Voltattorni, Carla: 1 article (01/2019)
2.	Cellini, Barbara: 1 article (01/2019)
3.	Cutruzzola, Francesca: 1 article (01/2019)
4.	Giardina, Giorgio: 1 article (01/2019)
5.	Montioli, Riccardo: 1 article (01/2019)
6.	Paiardini, Alessandro: 1 article (01/2019)
7.	Zanzoni, Serena: 1 article (01/2019)
8.	Breuer, Maximilian: 1 article (01/2018)
9.	Carl, Matthias: 1 article (01/2018)
10.	Hoffmann, Georg Friedrich: 1 article (01/2018)

1.	Gyrate Atrophy 01/01/2000 - "We recently showed that ornithine exhibits cytotoxicity to human retinal pigment epithelial (RPE) cell lines treated with the OAT inhibitor, 5-fluoromethylornithine (5-FMOrn), and suggested that this system may be an in vitro model of gyrate atrophy. " 01/01/2019 - "Among the over 50 gyrate atrophy-causing mutations of ornithine δ-aminotransferase (OAT), the R180T involves an active site residue located at the dimer interface, which in the crystal structure of OAT complexed with 5-fluoromethylornithine engages a salt bridge with the α-carboxylate of the substrate analogue. "
2.	Hyperammonemia 01/01/2018 - "Intriguingly, specific and irreversible inhibition of ornithine aminotransferase (OAT) by 5-fluoromethylornithine rescues zebrafish from lethal concentrations of ammonium acetate and corrects hyperammonemia-induced biochemical alterations. "
3.	Hypothermia 04/01/1993 - "Administration of 5-fluoromethylornithine (5FMOrn), a selective inactivator of ornithine aminotransferase (OAT), significantly reduced mortality, and it ameliorated most of the TAA-induced pathologic symptoms, such as hypothermia, decreased locomotor and exploratory behavior, pathologic liver function and amino acid patterns. "
4.	Hepatocellular Carcinoma (Hepatoma) 04/01/1998 - "Human RPE cells, human hepatoma cells, and human fibroblast cells were treated with 5-fluoromethylornithine (5-FMOrn), a specific irreversible inhibitor of OAT. "

1.	Ornithine-Oxo-Acid Transaminase (Ornithine Aminotransferase)
2.	Ornithine
3.	Salts
4.	Retinal Pigments (Pigments, Visual)
5.	Transaminases (Aminotransferases)
6.	Amino Acids
7.	ammonium acetate