fumagillol

from Penicillium jensenii; FR 65814 is an analog; structure given in first source

Also Known As:

1-Oxaspiro(2.5)octan-6-ol, 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-, (3R-(3alpha,4alpha(2R*,3R*),5beta,6beta))-

Networked: 22 relevant articles (5 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - fumagillol: 22
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        fumagillol: 22

Experts

1.	Ahn, Joong Bae: 1 article (04/2012)
2.	Chung, Hyun Cheol: 1 article (04/2012)
3.	Hong, Yong Sang: 1 article (04/2012)
4.	Kim, Chin: 1 article (04/2012)
5.	Kim, Dal-Hyun: 1 article (04/2012)
6.	Kim, Hye Ryun: 1 article (04/2012)
7.	Kim, Tae Won: 1 article (04/2012)
8.	Lee, Yoon Jung: 1 article (04/2012)
9.	Park, Kyung Soo: 1 article (04/2012)
10.	Rha, Sun Young: 1 article (04/2012)

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 08/01/1997 - "The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. " 04/01/1995 - "The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. " 02/01/1999 - "The efficacy of cis-diammine dichloroplatinum (CDDP) therapy in combination with continuous administration of angiogenesis inhibitor o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line previously established in our laboratory. " 04/01/1995 - "Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats."
2.	Neoplasm Metastasis (Metastasis) 10/01/1997 - "Effects on the liver of the antiangiogenesis agent O-(chloroacetyl-carbamoyl) fumagillol (TNP-470) on hematogenous metastasis of a human pancreatic carcinoma cell line were examined. " 05/01/1996 - "The effect of 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470) on tumor growth and metastasis is investigated. " 08/01/1997 - "The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. " 04/01/1995 - "The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. " 04/01/1995 - "Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats."
3.	Neoplasms (Cancer) 12/30/1994 - "Among these inhibitors, O-(chloroacetyl-carbamoyl) fumagillol (TNP-470) has been reported to have both antitumor and antimetastatic activities in rodent and human tumor models. " 05/01/1996 - "The effect of 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470) on tumor growth and metastasis is investigated. " 11/01/1993 - "The angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470) showed antitumor activity in three human cancer xenograft systems. " 04/01/1995 - "The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. " 10/01/1994 - "Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470) and cytotoxic agents in mice."
4.	Anaplastic Thyroid Carcinoma 08/01/1997 - "Therapeutic efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) for human anaplastic thyroid carcinoma in nude mice."
5.	Urinary Bladder Neoplasms (Bladder Cancer) 09/01/2000 - "To evaluate the efficacy of antiangiogenic therapy with O-(chloracetyl-carbamoyl) fumagillol (TNP-470) in a superficial and an invasive bladder cancer model in mice. "

Related Drugs and Biologics

1.	Angiogenesis Inhibitors
2.	O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)
3.	Angiostatins
4.	Cyclophosphamide (Cytoxan)
5.	fumagillin
6.	Cisplatin (Platino)
7.	Intercellular Signaling Peptides and Proteins (Growth Factors)
8.	Mitomycin (Mitomycin-C)
9.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
10.	Vincristine (Oncovin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)