songorine

RN given refers to parent cpd; diterpene alkaloid from Aconitum karakolicum Rap.

Also Known As:

songorine hydrochloride; (3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno(2,1-b)azocin-8(9H)-one

Networked: 8 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - songorine: 8

Experts

1.	Cao, Xiaoyu: 1 article (03/2021)
2.	Chen, Guanru: 1 article (03/2021)
3.	Chen, Junren: 1 article (03/2021)
4.	Li, Gangmin: 1 article (03/2021)
5.	Peng, Cheng: 1 article (03/2021)
6.	Peng, Fu: 1 article (03/2021)
7.	Wang, Pei: 1 article (03/2021)
8.	Xie, Xiaofang: 1 article (03/2021)
9.	Xiong, Liang: 1 article (03/2021)
10.	Xu, Xin: 1 article (03/2021)

Related Diseases

1.	Sepsis (Septicemia) 01/01/2021 - "Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis." 11/17/2023 - "Songorine treatment at 40 mg/kg mitigated sepsis-induced ALI, characterized by improved histopathology, lung injury score, and lung W/D weight ratio (p < 0.05). " 11/17/2023 - "The present study aimed to investigate the protective action and mechanism of songorine on sepsis-induced acute lung injury (ALI). " 11/17/2023 - "Songorine inhibits oxidative stress-related inflammation in sepsis-induced ALI via the activation of the PI3K/AKT/NRF2 signaling pathway." 11/17/2023 - "Furthermore, LY294002 (a PI3K inhibitor) treatment reversed the protective effect of songorine on sepsis-induced ALI. "
2.	Cardiotoxicity 01/01/2023 - "Songorine (S), neoline, talatizamine, 8-gingerol (G) and isoliquiritigenin (I), exhibiting stronger retention on the first-dimension CMMC column, were screened to have protective effects against DOX cardiotoxicity in the H9c2 cell model. "
3.	Lung Injury 11/17/2023 - "Songorine treatment at 40 mg/kg mitigated sepsis-induced ALI, characterized by improved histopathology, lung injury score, and lung W/D weight ratio (p < 0.05). "
4.	Acute Lung Injury 11/17/2023 - "The present study aimed to investigate the protective action and mechanism of songorine on sepsis-induced acute lung injury (ALI). " 11/17/2023 - "Songorine inhibits oxidative stress-related inflammation through PI3K/AKT/NRF2 signaling pathway to alleviate lipopolysaccharide-induced septic acute lung injury."
5.	Heart Injuries 01/01/2021 - "This study investigated the protective role of songorine in septic heart injury from the aspect of mitochondrial biogenesis. " 01/01/2021 - "Songorine activated Nrf2/ARE and NRF1 signaling cascades to rescue cardiomyocytes from endotoxin insult, suggesting that protection of mitochondrial biogenesis was a way for pharmacological intervention to prevent septic heart injury."

Related Drugs and Biologics

1.	neoline
2.	8-gingerol
3.	6- cyano- 5- methoxy- 12- methylindolo(2,3- a)carbazole
4.	isoliquiritigenin (GU 17)
5.	Alkaloids
6.	talatisamine
7.	aconine
8.	Caspase 3 (Caspase-3)
9.	Cytokines
10.	Anti-Anxiety Agents (Anxiolytics)