4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

06/01/1995 - "E3123 and SOD may be useful in the prophylaxis of clinical pancreatitis."
01/01/1994 - "E3123 showed favorable effects on the initial stage of severe acute pancreatitis and the effects were probably based on the inhibition of alpha 2M-TRY activity in serum."
01/01/1994 - "Group A: 1.5 mg/kg of E3123 subcutaneously (SC) each at 1 h before and after induction of pancreatitis. "
05/01/1992 - "These results indicate the possible usefulness of E3123 in the treatment of pancreatic duct obstructed pancreatitis."
11/01/1991 - "These results indicate that E-3123 plays its protective roles against pancreatitis in the subcellular compartment: lysosomes, mitochondria, cellular or organella membranes. "

03/01/1994 - "These results indicate the important roles of subcellular organelle fragility and impaired pancreatic energy metabolism in the pathogenesis of pancreatic injuries induced by common channel obstruction with intraductal hypertension, and also indicate the possible usefulness of E-3123 in the treatment of acute pancreatitis such as gallstone pancreatitis."
06/01/1995 - "To evaluate the protective effects of combined prophylaxis with 4-sulfamoylphenyl, 4-guanidinobenzoate methanesulfonate (E3123), potent new protease inhibitor, and superoxide dismutase (SOD), a free radical scavenger, against the multifactor-related pancreatic injuries that occur in acute pancreatitis. "

01/01/1994 - "Rats were divided into four groups according to difference of subdivided doses of E3123 with fixing the total dose at 3 mg/kg body weight. "
11/01/1990 - "Pancreatic wet weight/body weight also decreased after treatment with E-3123 in dogs injected with deoxycholic acid. "

03/01/1994 - "These results indicate the important roles of subcellular organelle fragility and impaired pancreatic energy metabolism in the pathogenesis of pancreatic injuries induced by common channel obstruction with intraductal hypertension, and also indicate the possible usefulness of E-3123 in the treatment of acute pancreatitis such as gallstone pancreatitis."

06/01/1995 - "In 24 rats the same protocol was followed as for the ischemia group, but 1 hour before and throughout the experiment, E3123 was infused at an hourly rate of 5 mg/kg, and before occlusion of the PBD and immediately after release of the occlusions of the PBD and arteries, SOD, 1 mg/kg, was injected intravenously (treatment group). "