|1.||Anderson, Karen S: 4 articles (02/2014 - 02/2008)|
|2.||Landau, Mark J: 3 articles (02/2014 - 09/2013)|
|3.||Sharma, Hitesh: 3 articles (02/2014 - 09/2013)|
|4.||Rathod, Pradipsinh K: 2 articles (11/2009 - 04/2002)|
|5.||Pornthanakasem, Wichai: 1 article (12/2014)|
|6.||Arunrut, Narong: 1 article (12/2014)|
|7.||Chareanchim, Wanwisa: 1 article (12/2014)|
|8.||Jaroenram, Wansadaj: 1 article (12/2014)|
|9.||Yongkiettrakul, Suganya: 1 article (12/2014)|
|10.||Suebsing, Rungkarn: 1 article (12/2014)|
07/01/1999 - "We investigated the capacity of dhfr-ts- to protect against heterologous infection by L. "
10/01/2007 - "falciparum DHFR-TS quadruple-mutant lines provides optimism for the future development of JPC2056 for the treatment of malaria infections."
10/01/2002 - "We have compared the efficacy of two Leishmania (Leishmania) major vaccines, one genetically attenuated (DHFR-TS deficient organisms), the other inactivated [autoclaved promastigotes (ALM) with bacillus Calmete-Guérin (BCG)], in protecting rhesus macaques (Macaca mulatta) against infection with virulent L. "
10/15/2013 - "gondii infections across the world, especially for those immunocompromised, underscores the need to understand TS-DHFR enzyme function and to find new avenues to exploit for the design of novel antiparasitic drugs. "
02/15/2014 - "To combat the infection, the enzyme responsible for nucleotide synthesis thymidylate synthase-dihydrofolate reductase (TS-DHFR) is a suitable drug target. "
|2.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/01/2010 - "Alignment with the DHFR-TS genes of other malaria parasites showed that a 231-residue DHFR domain and a 286-residue TS domain were seperated by a 101-aa linker region. "
02/05/2008 - "falciparum TS-DHFR is a highly selective, novel target for potential antifolate development in malaria."
12/31/1999 - "Interference with these essential protein-protein interactions could lead to new selective strategies to treat malaria resistant to traditional DHFR-TS inhibitors."
04/28/1998 - "vivax DHFR-TS gene sequence include an insertion of a short repetitive tandem array within the DHFR domain that is absent in another human malaria parasite, P. "
10/01/1996 - "In this paper, the DNA sequence of the dhfr-ts gene of 50 isolates from Vietnam and 2 clones (T9/94 and T9/96) isolated from a malaria patient from Thailand have been analyzed. "
01/01/1992 - "The ratio of TS/DHFR mRNAs in a number of human carcinoma cell lines varies from 0.4 to 9.9 but ranges from 1 to greater than 1.5 x 10(3) in a number of tumor samples. "
11/17/2005 - "This study shows that the pyrrolo[2,3-d]pyrimidine scaffold is conducive to dual DHFR-TS and tumor inhibitory activity, and the potency is determined by the 4-position substituent."
01/01/1992 - "Differences in the TS/DHFR mRNA ratio in tumors as compared with cultured cells reflects low levels of DHFR mRNA in some tumors. "
01/01/1992 - "Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction."
03/01/1994 - "The expression of several resistance markers (P-glycoprotein, glutathione S-transferase-pi, thymidylate synthase, dihydrofolate reductase) was analyzed in matched primary tumors and lymph node metastases from 21 patients with lung cancer using immunohistochemistry. "
|5.||Head and Neck Neoplasms (Head and Neck Cancer)
09/01/2001 - "This phase II study determined response rate of patients with locally advanced or metastatic head and neck cancer treated with pemetrexed disodium, a new multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyl transferase. "
|5.||Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
|9.||Messenger RNA (mRNA)
|10.||RNA (Ribonucleic Acid)