|1.||Olivier, Berend: 3 articles (06/2004 - 01/2002)|
|2.||van der Gugten, Jan: 3 articles (06/2004 - 01/2002)|
|3.||Bouwknecht, J Adriaan: 2 articles (06/2004 - 01/2002)|
|4.||Groenink, Lucianne: 2 articles (06/2004 - 09/2002)|
|5.||Hijzen, Theo H: 2 articles (09/2002 - 01/2002)|
|6.||Maes, Robert A A: 2 articles (09/2002 - 01/2002)|
|7.||Paylor, Richard E: 1 article (06/2004)|
|8.||Prous, J R: 1 article (06/2004)|
|9.||Bayes, M: 1 article (06/2004)|
|10.||Rabasseda, X: 1 article (06/2004)|
|1.||Panic Disorder (Panic Attack)
09/01/1996 - "The sample sizes of these two pilot studies are too small to draw firm conclusions on the efficacy of flesinoxan in panic disorder, but the present data are not encouraging in this respect. "
09/01/1996 - "The worsening of symptoms seen with the highest dose of flesinoxan is intriguing and might give a clue to the understanding of the mechanism underlying similar effects seen with antidepressants in panic disorder patients."
09/01/1996 - "The effects of flesinoxan, a potent and selective 5-HT1A agonist, were studied in two pilot studies in panic disorder patients to explore the role of 5-HT1A receptors in the mechanism of action of antipanic agents. "
09/01/1996 - "Effects of the 5-HT1A receptor agonist flesinoxan in panic disorder."
|2.||Hypertension (High Blood Pressure)
08/01/1996 - "The cardiovascular and renal functional responses to the 5-HT1A receptor agonist flesinoxan in two rat models of hypertension."
07/01/1991 - "The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. "
06/01/1992 - "These drugs, like ketanserin, urapidil and flesinoxan are used as tools to study the role of 5HT and its receptors in hypertension. "
01/01/1990 - "These drugs, like ketanserin, urapidil and flesinoxan are used as tools to study the role of 5-HT and its receptors in hypertension. "
10/01/1995 - "In view of potential antidepressant effects of flesinoxan, this study was undertaken to characterize its 5-HT1A properties in the rat brain using in vivo electrophysiology and hypothermia paradigms. "
10/01/1995 - "Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study."
07/14/2000 - "Flesinoxan (1.0 and 3.0 mg/kg) caused a relatively long-lasting hypothermia, but did not lower heart rate. "
10/01/1995 - "Similar degrees of hypothermia were achieved with 3 mg/kg of flesinoxan and 0.5 mg/kg of 8-OH-DPAT. "
10/01/1995 - "Subcutaneous administration of flesinoxan and 8-OH-DPAT produced a dose-dependent hypothermia. "
06/01/1992 - "4. Stimulation of 5-HT1A receptors alone, which is assumed to occur with flesinoxan, exerted antihypertensive activity only at low doses, without inducing reflex tachycardia at rest. "
09/04/1991 - "A decrease in blood pressure without reflex tachycardia was observed only with the lower dose of flesinoxan (0.1 mumol/kg). "
04/01/1991 - "Stimulation of 5-HT1A receptors alone (flesinoxan) suppresses reflex tachycardia by modulation of baroreceptor reflex and at high dose also diminishes exercise-induced increase in sympathetic tone."
07/14/2000 - "Flesinoxan reduced the stress-induced hyperthermia and the tachycardia evoked by the stress procedure. "
09/01/2002 - "Furthermore, the 5-HT(1A) receptor agonist flesinoxan dose-dependently antagonized SIH and stress-induced tachycardia in WT, but not in KO, mice. "
06/21/2004 - "In contrast, the physiological hyperthermia response showed anxiolytic-like effects of flesinoxan in both strains. "
07/14/2000 - "In this paradigm, 60 min after drug administration rectal temperature is measured, which causes hyperthermia of 1-1.5 degrees C (DeltaT) in about 10 min. Flesinoxan, a selective 5-HT(1A) receptor agonist with anxiolytic-like properties, causes hypothermia, which complicates interpretation of stress-induced hyperthermia. "
09/01/1997 - "Prior injection of the animals resulted in modest hyperthermia, that returned to baseline after 60 min. The anxiolytics diazepam and 5-HT1A receptor agonist flesinoxan dose-dependently suppressed SIH. "
|3.||Serotonin (5 Hydroxytryptamine)
|4.||5-HT1A Serotonin Receptor
|10.||Pindolol (LB 46)
|1.||Induced Hyperthermia (Thermotherapy)