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7 alpha-hydroxy-3-oxo-4-cholestenoic acid

unconjugated bile acid found in human blood; structure given in first source

Also Known As:

7-HOCA

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Cholestenes
        Cholestenones
        7 alpha-hydroxy-3-oxo-4-cholestenoic acid: 5

Experts

1.	Björkhem, Ingemar: 1 article (01/2017)
2.	Edström, Erik: 1 article (01/2017)
3.	Eggertsen, Gösta: 1 article (01/2017)
4.	Pikuleva, Irina: 1 article (01/2017)
5.	Saeed, Ahmed A: 1 article (01/2017)

Related Diseases

1.	Chronic Subdural Hematoma 06/22/1992 - "Identification of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in chronic subdural hematoma." 05/01/1995 - "A high concentration of a type of cholic acid, 7 alpha-hydroxy-3-oxo-4-cholestenoic acid, is observed in the content of chronic subdural hematoma. " 05/01/1995 - "The high concentration of this compound in both chronic subdural hematoma and subarachnoid hemorrhage suggests a possible role for 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in intracranial hemorrhagic disorders."
2.	Liver Diseases (Liver Disease) 08/28/1990 - "In controls and patients with liver disease, the level of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid was positively correlated to that of 3 beta,7 alpha-dihydroxy-5-cholestenoic acid and not to that of 7 alpha-hydroxy-4-cholesten-3-one. " 12/01/1989 - "The concentrations of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid were determined in plasma from patients with different liver diseases and compared with those of unconjugated and conjugated C24 bile acids. "
3.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 05/01/1995 - "Changes in the level of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid after subarachnoid hemorrhage." 05/01/1995 - "The high concentration of this compound in both chronic subdural hematoma and subarachnoid hemorrhage suggests a possible role for 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in intracranial hemorrhagic disorders."
4.	Hemorrhagic Disorders (Hemorrhagic Diathesis) 05/01/1995 - "The high concentration of this compound in both chronic subdural hematoma and subarachnoid hemorrhage suggests a possible role for 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in intracranial hemorrhagic disorders."
5.	Subdural Hematoma (Subdural Hemorrhage) 01/01/2017 - "We suggest that the major explanation for accumulation of 7-Hoca in subdural hematoma is a flux from the brain into the hematoma due to the high affinity to albumin and the high capacity of 7-Hoca to pass biomembranes. "

Related Drugs and Biologics

1.	Acids
2.	Cholic Acid
3.	Bile Acids and Salts (Bile Acids)
4.	Albumins
5.	3-hydroxy-5-cholestenoic acid
6.	7 alpha-hydroxy-4-cholesten-3-one